Amelioration of delayed-type hypersensitivity responses by IL-27 administration

Yoshiyuki Miyazaki, Yohei Shimanoe, Seng Wang, Hiroki Yoshida

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor α chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder.

本文言語英語
ページ(範囲)397-402
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
373
3
DOI
出版ステータス出版済み - 8 29 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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