Amide proton transfer imaging of adult diffuse gliomas: Correlation with histopathological grades

Osamu Togao, Takashi Yoshiura, Jochen Keupp, Hiwatashi Akio, Koji Yamashita, kazufumi kikuchi, Yuriko Suzuki, Satoshi Suzuki, Toru Iwaki, Nobuhiro Hata, Masahiro Mizoguchi, Koji Yoshimoto, Koji Sagiyama, Masaya Takahashi, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

138 引用 (Scopus)

抄録

BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4% in grade II gliomas (n = 8), 3.2 ± 0.9% in grade III gliomas (n = 10), and 4.1 ± 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.

元の言語英語
ページ(範囲)441-448
ページ数8
ジャーナルNeuro-Oncology
16
発行部数3
DOI
出版物ステータス出版済み - 3 1 2014

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Amides
Glioma
Protons
Necrosis
Cell Count
APT
Brain Neoplasms
Peptides

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

これを引用

Amide proton transfer imaging of adult diffuse gliomas : Correlation with histopathological grades. / Togao, Osamu; Yoshiura, Takashi; Keupp, Jochen; Akio, Hiwatashi; Yamashita, Koji; kikuchi, kazufumi; Suzuki, Yuriko; Suzuki, Satoshi; Iwaki, Toru; Hata, Nobuhiro; Mizoguchi, Masahiro; Yoshimoto, Koji; Sagiyama, Koji; Takahashi, Masaya; Honda, Hiroshi.

:: Neuro-Oncology, 巻 16, 番号 3, 01.03.2014, p. 441-448.

研究成果: ジャーナルへの寄稿記事

Togao, Osamu ; Yoshiura, Takashi ; Keupp, Jochen ; Akio, Hiwatashi ; Yamashita, Koji ; kikuchi, kazufumi ; Suzuki, Yuriko ; Suzuki, Satoshi ; Iwaki, Toru ; Hata, Nobuhiro ; Mizoguchi, Masahiro ; Yoshimoto, Koji ; Sagiyama, Koji ; Takahashi, Masaya ; Honda, Hiroshi. / Amide proton transfer imaging of adult diffuse gliomas : Correlation with histopathological grades. :: Neuro-Oncology. 2014 ; 巻 16, 番号 3. pp. 441-448.
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title = "Amide proton transfer imaging of adult diffuse gliomas: Correlation with histopathological grades",
abstract = "BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4{\%} in grade II gliomas (n = 8), 3.2 ± 0.9{\%} in grade III gliomas (n = 10), and 4.1 ± 1.0{\%} in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.",
author = "Osamu Togao and Takashi Yoshiura and Jochen Keupp and Hiwatashi Akio and Koji Yamashita and kazufumi kikuchi and Yuriko Suzuki and Satoshi Suzuki and Toru Iwaki and Nobuhiro Hata and Masahiro Mizoguchi and Koji Yoshimoto and Koji Sagiyama and Masaya Takahashi and Hiroshi Honda",
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TY - JOUR

T1 - Amide proton transfer imaging of adult diffuse gliomas

T2 - Correlation with histopathological grades

AU - Togao, Osamu

AU - Yoshiura, Takashi

AU - Keupp, Jochen

AU - Akio, Hiwatashi

AU - Yamashita, Koji

AU - kikuchi, kazufumi

AU - Suzuki, Yuriko

AU - Suzuki, Satoshi

AU - Iwaki, Toru

AU - Hata, Nobuhiro

AU - Mizoguchi, Masahiro

AU - Yoshimoto, Koji

AU - Sagiyama, Koji

AU - Takahashi, Masaya

AU - Honda, Hiroshi

PY - 2014/3/1

Y1 - 2014/3/1

N2 - BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4% in grade II gliomas (n = 8), 3.2 ± 0.9% in grade III gliomas (n = 10), and 4.1 ± 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.

AB - BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4% in grade II gliomas (n = 8), 3.2 ± 0.9% in grade III gliomas (n = 10), and 4.1 ± 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.

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DO - 10.1093/neuonc/not158

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JO - Neuro-Oncology

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