抄録
BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4% in grade II gliomas (n = 8), 3.2 ± 0.9% in grade III gliomas (n = 10), and 4.1 ± 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 441-448 |
| ページ数 | 8 |
| ジャーナル | Neuro-Oncology |
| 巻 | 16 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 3 1 2014 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Clinical Neurology
- Cancer Research
これを引用
Amide proton transfer imaging of adult diffuse gliomas : Correlation with histopathological grades. / Togao, Osamu; Yoshiura, Takashi; Keupp, Jochen; Akio, Hiwatashi; Yamashita, Koji; kikuchi, kazufumi; Suzuki, Yuriko; Suzuki, Satoshi; Iwaki, Toru; Hata, Nobuhiro; Mizoguchi, Masahiro; Yoshimoto, Koji; Sagiyama, Koji; Takahashi, Masaya; Honda, Hiroshi.
：: Neuro-Oncology, 巻 16, 番号 3, 01.03.2014, p. 441-448.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Amide proton transfer imaging of adult diffuse gliomas
T2 - Correlation with histopathological grades
AU - Togao, Osamu
AU - Yoshiura, Takashi
AU - Keupp, Jochen
AU - Akio, Hiwatashi
AU - Yamashita, Koji
AU - kikuchi, kazufumi
AU - Suzuki, Yuriko
AU - Suzuki, Satoshi
AU - Iwaki, Toru
AU - Hata, Nobuhiro
AU - Mizoguchi, Masahiro
AU - Yoshimoto, Koji
AU - Sagiyama, Koji
AU - Takahashi, Masaya
AU - Honda, Hiroshi
PY - 2014/3/1
Y1 - 2014/3/1
N2 - BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4% in grade II gliomas (n = 8), 3.2 ± 0.9% in grade III gliomas (n = 10), and 4.1 ± 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.
AB - BackgroundAmide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas.MethodsThirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 ± 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets ω =-6 to +6 ppm (step 0.5 ppm). δB0 maps were acquired separately for a point-by-point δB0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)asym = (S[-3.5 ppm]-S [+3.5 ppm])/S0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density.ResultsThe mean APT SI values were 2.1 ± 0.4% in grade II gliomas (n = 8), 3.2 ± 0.9% in grade III gliomas (n = 10), and 4.1 ± 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P <. 05) and grades III and IV (P <. 05), as well as between grades II and IV (P <. 001). There were positive correlations between APT SI and Ki-67 LI (P =. 01, R = 0.43) and between APT SI and cell density (P <. 05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P <. 001).ConclusionsAPT imaging can predict the histopathological grades of adult diffuse gliomas.
UR - http://www.scopus.com/inward/record.url?scp=84894287132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894287132&partnerID=8YFLogxK
U2 - 10.1093/neuonc/not158
DO - 10.1093/neuonc/not158
M3 - Article
C2 - 24305718
AN - SCOPUS:84894287132
VL - 16
SP - 441
EP - 448
JO - Neuro-Oncology
JF - Neuro-Oncology
SN - 1522-8517
IS - 3
ER -