抄録
A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.
本文言語 | 英語 |
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ページ(範囲) | 191-192 |
ページ数 | 2 |
ジャーナル | Nucleic acids symposium series (2004) |
号 | 49 |
出版ステータス | 出版済み - 2005 |
All Science Journal Classification (ASJC) codes
- Medicine(all)