Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

Kazuteru Usui, Mitsuhiro Fukuda, Mariko Aso, Hiroshi Suemune

研究成果: ジャーナルへの寄稿会談の抜粋

抄録

A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

元の言語英語
ページ(範囲)191-192
ページ数2
ジャーナルNucleic acids symposium series (2004)
発行部数49
出版物ステータス出版済み - 1 1 2005

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Amines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors. / Usui, Kazuteru; Fukuda, Mitsuhiro; Aso, Mariko; Suemune, Hiroshi.

:: Nucleic acids symposium series (2004), 番号 49, 01.01.2005, p. 191-192.

研究成果: ジャーナルへの寄稿会談の抜粋

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T1 - Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

AU - Usui, Kazuteru

AU - Fukuda, Mitsuhiro

AU - Aso, Mariko

AU - Suemune, Hiroshi

PY - 2005/1/1

Y1 - 2005/1/1

N2 - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

AB - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

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M3 - Meeting Abstract

SP - 191

EP - 192

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

SN - 1746-8272

IS - 49

ER -