抄録
A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 191-192 |
| ページ数 | 2 |
| ジャーナル | Nucleic acids symposium series (2004) |
| 発行部数 | 49 |
| 出版物ステータス | 出版済み - 1 1 2005 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
これを引用
Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors. / Usui, Kazuteru; Fukuda, Mitsuhiro; Aso, Mariko; Suemune, Hiroshi.
：: Nucleic acids symposium series (2004), 番号 49, 01.01.2005, p. 191-192.研究成果: ジャーナルへの寄稿 › 会談の抜粋
}
TY - JOUR
T1 - Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.
AU - Usui, Kazuteru
AU - Fukuda, Mitsuhiro
AU - Aso, Mariko
AU - Suemune, Hiroshi
PY - 2005/1/1
Y1 - 2005/1/1
N2 - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.
AB - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.
UR - http://www.scopus.com/inward/record.url?scp=39049195972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049195972&partnerID=8YFLogxK
M3 - Meeting Abstract
SP - 191
EP - 192
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
SN - 1746-8272
IS - 49
ER -