Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

Kazuteru Usui; Mitsuhiro Fukuda; Mariko Aso; Hiroshi Suemune

Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

Kazuteru Usui, Mitsuhiro Fukuda, Mariko Aso, Hiroshi Suemune

医薬化学

研究成果: Contribution to journal › Meeting Abstract

抄録

A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

本文言語	英語
ページ（範囲）	191-192
ページ数	2
ジャーナル	Nucleic acids symposium series (2004)
号	49
出版ステータス	出版済み - 2005

All Science Journal Classification (ASJC) codes

Medicine(all)

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引用スタイル

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author = "Kazuteru Usui and Mitsuhiro Fukuda and Mariko Aso and Hiroshi Suemune",

year = "2005",

language = "English",

pages = "191--192",

journal = "Nucleic acids symposium series (2004)",

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T1 - Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

AU - Usui, Kazuteru

AU - Fukuda, Mitsuhiro

AU - Aso, Mariko

AU - Suemune, Hiroshi

PY - 2005

Y1 - 2005

N2 - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

AB - A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

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M3 - Meeting Abstract

C2 - 17150698

AN - SCOPUS:39049195972

SP - 191

EP - 192

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

SN - 1746-8272

IS - 49

ER -