Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

Kazuteru Usui, Mitsuhiro Fukuda, Mariko Aso, Hiroshi Suemune

研究成果: Contribution to journalMeeting Abstract

抄録

A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

本文言語英語
ページ(範囲)191-192
ページ数2
ジャーナルNucleic acids symposium series (2004)
49
出版ステータス出版済み - 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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