Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Shuji Akai, Yoshitaka Hamashima, Noriyuki Ohneda, Hiromichi Odajima, Takashi Ohshima

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

A study of ammonium salt-accelerated hydrazinolysis of unactivated amides is described. We first studied the reaction mechanism by kinetic experiments and DFT calculations and found that cooperation of the hydrazinium salt and hydrazine is important for promoting the cleavage of unactivated amides. Next, we applied the reaction to a microwave flow process, and the amine products were isolated on a multigram scale.

元の言語英語
ページ(範囲)588-594
ページ数7
ジャーナルOrganic Process Research and Development
23
発行部数4
DOI
出版物ステータス出版済み - 4 19 2019

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hydrazine
Ammonium Compounds
Amides
amides
Salts
Microwaves
salts
microwaves
hydrazines
Discrete Fourier transforms
Amines
cleavage
amines
Kinetics
kinetics
products
Experiments
hydrazinium

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

これを引用

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides : Mechanistic Investigation and Application to a Microwave Flow Process. / Noshita, Megumi; Shimizu, Yuhei; Morimoto, Hiroyuki; Akai, Shuji; Hamashima, Yoshitaka; Ohneda, Noriyuki; Odajima, Hiromichi; Ohshima, Takashi.

:: Organic Process Research and Development, 巻 23, 番号 4, 19.04.2019, p. 588-594.

研究成果: ジャーナルへの寄稿記事

Noshita, Megumi ; Shimizu, Yuhei ; Morimoto, Hiroyuki ; Akai, Shuji ; Hamashima, Yoshitaka ; Ohneda, Noriyuki ; Odajima, Hiromichi ; Ohshima, Takashi. / Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides : Mechanistic Investigation and Application to a Microwave Flow Process. :: Organic Process Research and Development. 2019 ; 巻 23, 番号 4. pp. 588-594.
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AU - Akai, Shuji

AU - Hamashima, Yoshitaka

AU - Ohneda, Noriyuki

AU - Odajima, Hiromichi

AU - Ohshima, Takashi

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