抄録
A study of ammonium salt-accelerated hydrazinolysis of unactivated amides is described. We first studied the reaction mechanism by kinetic experiments and DFT calculations and found that cooperation of the hydrazinium salt and hydrazine is important for promoting the cleavage of unactivated amides. Next, we applied the reaction to a microwave flow process, and the amine products were isolated on a multigram scale.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 588-594 |
| ページ数 | 7 |
| ジャーナル | Organic Process Research and Development |
| 巻 | 23 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 4 19 2019 |
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All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry
これを引用
Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides : Mechanistic Investigation and Application to a Microwave Flow Process. / Noshita, Megumi; Shimizu, Yuhei; Morimoto, Hiroyuki; Akai, Shuji; Hamashima, Yoshitaka; Ohneda, Noriyuki; Odajima, Hiromichi; Ohshima, Takashi.
：: Organic Process Research and Development, 巻 23, 番号 4, 19.04.2019, p. 588-594.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides
T2 - Mechanistic Investigation and Application to a Microwave Flow Process
AU - Noshita, Megumi
AU - Shimizu, Yuhei
AU - Morimoto, Hiroyuki
AU - Akai, Shuji
AU - Hamashima, Yoshitaka
AU - Ohneda, Noriyuki
AU - Odajima, Hiromichi
AU - Ohshima, Takashi
PY - 2019/4/19
Y1 - 2019/4/19
N2 - A study of ammonium salt-accelerated hydrazinolysis of unactivated amides is described. We first studied the reaction mechanism by kinetic experiments and DFT calculations and found that cooperation of the hydrazinium salt and hydrazine is important for promoting the cleavage of unactivated amides. Next, we applied the reaction to a microwave flow process, and the amine products were isolated on a multigram scale.
AB - A study of ammonium salt-accelerated hydrazinolysis of unactivated amides is described. We first studied the reaction mechanism by kinetic experiments and DFT calculations and found that cooperation of the hydrazinium salt and hydrazine is important for promoting the cleavage of unactivated amides. Next, we applied the reaction to a microwave flow process, and the amine products were isolated on a multigram scale.
UR - http://www.scopus.com/inward/record.url?scp=85064595130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064595130&partnerID=8YFLogxK
U2 - 10.1021/acs.oprd.8b00424
DO - 10.1021/acs.oprd.8b00424
M3 - Article
AN - SCOPUS:85064595130
VL - 23
SP - 588
EP - 594
JO - Organic Process Research and Development
JF - Organic Process Research and Development
SN - 1083-6160
IS - 4
ER -