TY - JOUR
T1 - Amyloid β-protein gene duplication is not common in Alzheimer's disease
T2 - Analysis by polymorphic restriction fragments
AU - Furuya, Hirokazu
AU - Sasaki, Hiroyuki
AU - Goto, Ikuo
AU - Wong, Caine W.
AU - Glenner, George G.
AU - Sakaki, Yoshiyuki
PY - 1988/1/15
Y1 - 1988/1/15
N2 - The amyloid β-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.
AB - The amyloid β-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.
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U2 - 10.1016/0006-291X(88)90488-3
DO - 10.1016/0006-291X(88)90488-3
M3 - Article
C2 - 2892492
AN - SCOPUS:0023839174
VL - 150
SP - 75
EP - 81
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -