Amyloid β-protein gene duplication is not common in Alzheimer's disease: Analysis by polymorphic restriction fragments

Hirokazu Furuya, Hiroyuki Sasaki, Ikuo Goto, Caine W. Wong, George G. Glenner, Yoshiyuki Sakaki

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

The amyloid β-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.

本文言語英語
ページ(範囲)75-81
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
150
1
DOI
出版ステータス出版済み - 1月 15 1988

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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