An analysis of telomere length in sarcoidosis

Zhi Guan Jing, Toyoki Maeda, Masahiro Sugano, Jun Ichi Oyama, Yoshihiro Higuchi, Tomokazu Suzuki, Naoki Makino

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

We investigated telomere (terminal restriction fragment [TRF]) length in 111 patients with sarcoidosis regarding both the mean TRF length and the telomere length distribution. A significant decrease was observed in the mean TRF length in sarcoidosis patients in comparison to the age-matched controls, whereas a decreased telomere length was only associated with age in men. The mean TRF shortening seemed to be accelerated in men in their 30s and 50s and in women in their 40s and 50s. We also found a significant decrease with age of telomeres with lengths of 9.4-6.6 kb in men and women in their 20s and an increase of telomeres with lengths of 4.4-2.3 kb in men and women in their 20s and in men in their 50s in sarcoidosis patients versus in the controls who were in their 20s and 50s. These findings suggest the occurrence of age-advanced changes in telomere length in patients with sarcoidosis, regardless of the patient age at the onset of sarcoidosis.

本文言語英語
ページ(範囲)1199-1203
ページ数5
ジャーナルJournals of Gerontology - Series A Biological Sciences and Medical Sciences
62
11
DOI
出版ステータス出版済み - 11 2007

All Science Journal Classification (ASJC) codes

  • 加齢科学
  • 老年医学

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