TY - GEN

T1 - An approximation model of myocardial crossbridge for weak coupling calculation of left ventricle model and circulation model

AU - Amano, Akira

AU - Takada, Yasuhiro

AU - Lu, Jianyin

AU - Shimayoshi, Takao

AU - Matsuda, Tetsuya

PY - 2008

Y1 - 2008

N2 - It is necessary to use complicated myocardial cell model and heart model to evaluate the regional energy production and consumption which leads to the unrealistic computational time. In this research, a left ventricle (LV) simulation model was constructed which includes accurate myocardial cell model. In order to simulate the model in realistic time, we introduced an approximation model of the crossbridge model which can be calculated with weak coupling calculation. The LV model was combined with a circulation model to validate the proposed model by calculating the hemodynamics parameters and ventricular energetics indices. The ESPVR (End Systolic Pressure Volume Relation) showed linear relation, and also the PVA - ATP consumption relation showed linear relation which are widely known as the physiological characteristics of mammalian hearts. From these results, we can say that the model can be used as a model for physiological simulation experiments which are related to the ventricular energetics.

AB - It is necessary to use complicated myocardial cell model and heart model to evaluate the regional energy production and consumption which leads to the unrealistic computational time. In this research, a left ventricle (LV) simulation model was constructed which includes accurate myocardial cell model. In order to simulate the model in realistic time, we introduced an approximation model of the crossbridge model which can be calculated with weak coupling calculation. The LV model was combined with a circulation model to validate the proposed model by calculating the hemodynamics parameters and ventricular energetics indices. The ESPVR (End Systolic Pressure Volume Relation) showed linear relation, and also the PVA - ATP consumption relation showed linear relation which are widely known as the physiological characteristics of mammalian hearts. From these results, we can say that the model can be used as a model for physiological simulation experiments which are related to the ventricular energetics.

UR - http://www.scopus.com/inward/record.url?scp=61849119447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61849119447&partnerID=8YFLogxK

U2 - 10.1109/iembs.2008.4649313

DO - 10.1109/iembs.2008.4649313

M3 - Conference contribution

C2 - 19162816

AN - SCOPUS:61849119447

SN - 9781424418152

T3 - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

SP - 957

EP - 960

BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08

PB - IEEE Computer Society

T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08

Y2 - 20 August 2008 through 25 August 2008

ER -