An aprotic polar solvent assisted size-tuning method for microfluidic production of lipid-based drug nanocarriers with various sizes

Niko Kimura, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

This paper reports a microfluidic methodology for precise size-tuning of lipid nanoparticles (LNPs) with various sizes by using lipid solvents composed of a protic or an aprotic or mixed solvents. This method expanded the size-tunable range of the iLiNP device while kept the precise size controllability and the mass productivity. In addition, the produced siRNA-loaded LNPs with various sizes were evaluated in vitro experiments and confirmed effective gene-silencing activity and intracellular uptake depending on the LNP sizes. This LNP size-tuning methodology is expected to be a breakthrough in the current limited size-tunability of LNPs.

本文言語英語
ホスト出版物のタイトルMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版社Chemical and Biological Microsystems Society
ページ1021-1022
ページ数2
ISBN(電子版)9781733419017
出版ステータス出版済み - 2020
外部発表はい
イベント24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
継続期間: 10月 4 202010月 9 2020

出版物シリーズ

名前MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

会議

会議24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

!!!All Science Journal Classification (ASJC) codes

  • 化学工学(その他)
  • バイオエンジニアリング
  • 化学 (全般)
  • 制御およびシステム工学

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