An association between salivary gland disease and serological abnormalities in Sjogren's syndrome

Seiji Nakamura, Akiko Ikebe-Hiroki, Masanori Shinohara, Yukiko Ohyama, Takefumi Mouri, Masanori Sasaki, Kanemitsu Shirasuna, Kikuo Nomoto

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

In the labial salivary glands (LSGs) of 16 primary and 18 secondary Sjogren's syndrome (SS) patients, infiltrating lymphocytes were histologically and immunohistochemically examined; also, the serum levels of rheumatoid factor, antinuclear antibodies, anti-DNA antibodies, anti-SS-A and anti-SS-B antibodies, and immunoglobulins (including IgG, IgM and IgA) were all assayed. An immunohistochemical analysis of the lymphocyte subsets in LSGs revealed that severe lymphocytic infiltration was frequently accompanied by marked B cell accumulation both in primary and secondary SS patients. Furthermore, local B cell accumulation was also closely associated with elevated levels of anti-SS-A and anti-SS-B antibodies and IgG, and this association was statistically significant in the group with primary SS but not in the group with secondary SS. Thus, local lymphocytic infiltration, especially B cell accumulation, in the salivary glands is suggested to be involved in serological abnormalities in primary SS, while complicated autoimmune diseases other than SS may also be involved in serological abnormalities in secondary SS.

本文言語英語
ページ(範囲)426-430
ページ数5
ジャーナルJournal of Oral Pathology and Medicine
26
9
DOI
出版ステータス出版済み - 1 1 1997

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 口腔外科
  • 耳鼻咽喉科学
  • 癌研究
  • 歯周病学

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