An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Shigeki Sasaki, Yasutaka Takase, Kenji Koga

研究成果: Contribution to journalArticle

6 被引用数 (Scopus)

抄録

An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.

本文言語英語
ページ(範囲)6051-6054
ページ数4
ジャーナルTetrahedron Letters
31
42
DOI
出版ステータス出版済み - 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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