An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Shigeki Sasaki; Yasutaka Takase; Kenji Koga

doi:10.1016/S0040-4039(00)98026-2

An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Shigeki Sasaki, Yasutaka Takase, Kenji Koga

研究成果: Contribution to journal › Article

6 被引用数 (Scopus)

抄録

An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.

本文言語	英語
ページ（範囲）	6051-6054
ページ数	4
ジャーナル	Tetrahedron Letters
巻	31
号	42
DOI	https://doi.org/10.1016/S0040-4039(00)98026-2
出版ステータス	出版済み - 1990
外部発表	はい

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

文献へのアクセス

10.1016/S0040-4039(00)98026-2

フィンガープリント「An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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abstract = "An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.",

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