抄録
An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.
本文言語 | 英語 |
---|---|
ページ(範囲) | 6051-6054 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 31 |
号 | 42 |
DOI | |
出版ステータス | 出版済み - 1990 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 生化学
- 創薬
- 有機化学