An electrophysiological analysis of brainstem function in rats with diabetes mellitus

Deshan Liu, Wei Gao, Weiwei Lin, Toyoshi Inoguchi, Ryoichi Takayanagi

    研究成果: Chapter in Book/Report/Conference proceedingConference contribution

    抄録

    Diabetes mellitus (DM) can affect both the peripheral and the central nervous system (CNS). However, central deficits are documented less well than peripheral deficits. We believe that brainstem auditory evoked potential (BAEP) studies help in the understanding of the dysfunction of the ascending sensory pathways at various levels. Twenty-two male rats were randomly divided into two groups: normal control rats (group NC) and diabetic rats (group DM). DM was induced by a single intraperitoneal injection of 1% streptozotocin (STZ, 60 mg/kg of body weight) in all rats of DM group. After six weeks, Absolute peak latencies (PLs) of waves I, II, III, IV and V, and interpeak latencies (IPL) of I-III, III-V and I-V were measured in each rats of the experiment. Then serum insulin levels, blood biochemical indices, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. The diabetic status of the rats of DM group was kept uncontrolled throughout the study. Body weight and blood glucose of non-fasting rats (BG) in DM group were significantly altered than those of NC group (P<0.05, respectively). Neuroelectrophysiological results showed that all wave latencies and IPL I-III, I-V in DM group were prolonged at 6 weeks after induction of diabetes, and delay in waves III, V and IPL I-III, I-V was significant compared with NC group (P<0.05, respectively). It was discovered that central conduction time (CCT) of rats with diabetes had a close correlation with fasting insulin (FINS), fasting blood glucose (FBG) and MDA. These findings indicate that experimentally induced diabetes can result in a brain dysfunction as measured by the increased latencies of the IPL I-V of BAEP. In conclusion, BAEP prove to be a useful non-invasive neuroelectrophysiological technique that may help unravel both the relative involvement of the peripheral and central nervous systems in the course of diabetes mellitus, and the evolution of diabetic neuropathy.

    本文言語英語
    ホスト出版物のタイトル2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings
    ページ7372-7375
    ページ数4
    DOI
    出版ステータス出版済み - 2011
    イベント2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Nanjing, 中国
    継続期間: 6 24 20116 26 2011

    出版物シリーズ

    名前2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings

    その他

    その他2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011
    Country中国
    CityNanjing
    Period6/24/116/26/11

    All Science Journal Classification (ASJC) codes

    • Computer Networks and Communications
    • Environmental Engineering
    • Transportation

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