An enteric-coated dry emulsion formulation for oral insulin delivery

Eiichi Toorisaka, Masakazu Hashida, Noriho Kamiya, Hiroshige Ono, Yuko Kokazu, Masahiro Goto

研究成果: Contribution to journalArticle査読

83 被引用数 (Scopus)

抄録

A novel oral dosage formulation of insulin consisting of a surfactant, a vegetable oil, and a pH-responsive polymer has been developed. First, a solid-in-oil (S/O) suspension containing a surfactant-insulin complex was prepared. Solid-in-oil-in-water (S/O/W) emulsions were obtained by homogenizing the S/O suspension and the aqueous solution of hydroxypropylmethylcellulose phthalate (HPMCP). A microparticulate solid emulsion formulation was successfully prepared from the S/O/W emulsions by extruding them to an acidic aqueous solution, followed by lyophilization. The insulin release from the resultant dry emulsion responded to the change in external environment simulated by gastrointestinal conditions, suggesting that the new enteric-coated dry emulsion formulation is potentially applicable for the oral delivery of peptide and protein drugs.

本文言語英語
ページ(範囲)91-96
ページ数6
ジャーナルJournal of Controlled Release
107
1
DOI
出版ステータス出版済み - 9 20 2005

All Science Journal Classification (ASJC) codes

  • 薬科学

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