An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors

Kohji Okamura, Yoichi Yamada, Yoshiyuki Sakaki, Takashi Ito

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

Mouse Impact is the sole imprinted gene mapped to chromosome 18 to date. Despite its remarkable evolutionary conservation, human IMPACT was shown to escape genomic imprinting. Here we identified Hrh4 and Osbpl1 as the distal and proximal nearest neighbors of Impact, respectively, and found that both genes are expressed biallelically. Thus, in contrast with most imprinted genes, Impact fails to show apparent physical clustering with other imprinted genes. Since Impact not only lies in an intergenic region but also consists of 11 exons, it does not seem to be an imprinted gene generated by a retrotransposition. Hazardous effects of overexpressed Impact, a genomic segment containing paralogues of Hrh4 and Osbpl1 but not of Impact, and enhanced promoter activity in the mouse led us to propose an alternative model. This model assumes that segmental duplication followed by enhancement of the promoter activity in the lineage to mouse is responsible for the species-specific imprinting of Impact.

元の言語英語
ページ(範囲)381-390
ページ数10
ジャーナルDNA Research
11
発行部数6
DOI
出版物ステータス出版済み - 12 1 2004
外部発表Yes

Fingerprint

Genomic Imprinting
Genes
Genomic Segmental Duplications
Chromosomes, Human, Pair 18
Intergenic DNA
Cluster Analysis
Exons

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

これを引用

An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. / Okamura, Kohji; Yamada, Yoichi; Sakaki, Yoshiyuki; Ito, Takashi.

:: DNA Research, 巻 11, 番号 6, 01.12.2004, p. 381-390.

研究成果: ジャーナルへの寄稿記事

Okamura, Kohji ; Yamada, Yoichi ; Sakaki, Yoshiyuki ; Ito, Takashi. / An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. :: DNA Research. 2004 ; 巻 11, 番号 6. pp. 381-390.
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