An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system

Hiroshi Yoshida, Tetsuya Bando, Taro Mito, Hideyo Ohuchi, Sumihare Noji

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination.

元の言語英語
記事番号4335
ジャーナルScientific reports
4
DOI
出版物ステータス出版済み - 3 11 2014

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Gryllidae
Leg
Fats
Regeneration
Organ Size
RNA Interference
Cell Division
Growth

All Science Journal Classification (ASJC) codes

  • General

これを引用

An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system. / Yoshida, Hiroshi; Bando, Tetsuya; Mito, Taro; Ohuchi, Hideyo; Noji, Sumihare.

:: Scientific reports, 巻 4, 4335, 11.03.2014.

研究成果: ジャーナルへの寄稿記事

Yoshida, Hiroshi ; Bando, Tetsuya ; Mito, Taro ; Ohuchi, Hideyo ; Noji, Sumihare. / An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system. :: Scientific reports. 2014 ; 巻 4.
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