An HDAC inhibitor increases AcMNPV gene expression in mammalian cells

Ryosuke Fujita, Daisuke Ohtsuka, Ken Sahara, Shinichiro Asano, Hisanori Bando

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is used as a safer viral vector in mammalian cells with potential applications in gene therapy. However, the mechanism for the insusceptibility of mammalian cells to proliferative infection by entomopathogenic viruses is not well understood. Here, we studied the significance of epigenetic modifications such as histone acetylation, histone methylation and HP1 accumulation for AcMNPV gene expression in mammalian BHK cells. Real-time PCR and chromatin immunoprecipitation with sodium butyrate revealed an important relationship between viral gene expression and histone acetylation, with implications for a mechanism of suppression of AcMNPV gene expression in BHK cells.

本文言語英語
ページ(範囲)577-581
ページ数5
ジャーナルArchives of Virology
155
4
DOI
出版ステータス出版済み - 4月 2010
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • ウイルス学

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