An HLA-linked immune suppression gene in man

T. Sasazuki; H. Kaneoka; Y. Nishimura; R. Kaneoka; M. Hayama; H. Ohkuni

An HLA-linked immune suppression gene in man

T. Sasazuki, H. Kaneoka, Y. Nishimura, R. Kaneoka, M. Hayama, H. Ohkuni

研究成果: Contribution to journal › Article › 査読

抄録

Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3.209 at θ = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.

本文言語	英語
ページ（範囲）	297-311
ページ数	15
ジャーナル	Journal of Experimental Medicine
巻	152
号	2 II
出版ステータス	出版済み - 1980
外部発表	はい

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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引用スタイル

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AU - Ohkuni, H.

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