抄録
Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3.209 at θ = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.
本文言語 | 英語 |
---|---|
ページ(範囲) | 297-311 |
ページ数 | 15 |
ジャーナル | Journal of Experimental Medicine |
巻 | 152 |
号 | 2 II |
出版ステータス | 出版済み - 1980 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 免疫アレルギー学
- 免疫学