An immunoassay method for the pharmacokinetics of 5-fluorouracil in patients with gastric cancer administered adjuvant chemotherapy

Hideo Matsumoto, Masaharu Higashida, Hisako Kubota, Haruaki Murakami, Kosuke Tsutsumi, Hiroshi Nakashima, Yasuo Oka, Hideo Okumura, Masafumi Nakamura, Toshihiro Hirai

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

Conventional gas chromatography-mass spectrometry (GC-MS) was compared with a new immunoassay method for measuring plasma (5-FU) concentrations in adjuvant chemotherapy with TS-1 for patients with gastric cancer. TS-1 was administered orally to patients after gastrectomy. Blood samples for pharmacokinetic analysis were collected on the seventh day of treatment. The mean area under the time concentration curve (AUC)0-8, half-life (t1/2), and maximum drug concentration (Cmax) obtained by the two methods were as follows: GC-MS, 847.9 μg/ml/hr, 2.76 h, and 186.6 ng/ml; and immunoassay, 1311.2 μg/ml/hr, 3.5 h, and 259.8 ng/ml. Significant correlations were observed for AUC0-8(p=0.0001), Cmax (p=0.0007), and changes in the 5-FU concentration in blood over time (p=0.018) for the two methods. Compared with the conventional GC-MS method, the new immunoassay method provides similar results, but is simpler and results can be obtained earlier. This method will be useful for monitoring the 5-FU concentration in serum from patients with gastric cancer receiving TS-1.

本文言語英語
ページ(範囲)5111-5114
ページ数4
ジャーナルAnticancer research
32
11
出版ステータス出版済み - 11月 1 2012
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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