An in vitro system for screening anti-hepatitis b virus drugs

Keiji Ueda, Toshiki Tsurimoto, Takemitsu Nagahata, Osamu Chisaka, Kenichi Matsubarai

研究成果: Contribution to journalArticle査読

70 被引用数 (Scopus)

抄録

A human hepatoblastoma cell line (HB 611) that continuously synthesizes hepatitis B viral (HBV) DNA was grown in the presence of various inhibitors of DNA synthesis, and the DNA from the cells was analyzed by the Southern blotting method to examine selective inhibition of the viral DNA synthesis. Among those that showed selective inhibition, and interferons α and β, acyclovir, and dideoxy cytidine were effective. This system should be useful for screening new antiviral agents against HBV.

本文言語英語
ページ(範囲)213-216
ページ数4
ジャーナルVirology
169
1
DOI
出版ステータス出版済み - 1 1 1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • ウイルス学

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