An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis

Makoto Takahashi, Kazuhiko Nakamura, Kuniomi Honda, Yousuke Kitamura, Takahiro Mizutani, Yuzuru Araki, Teppei Kabemura, Yoshiharu Chijiiwa, Naohiko Harada, Hajime Nawata

研究成果: Contribution to journalArticle査読

82 被引用数 (Scopus)

抄録

Evidence suggests that CD4+CD25+ regulatory T cells play a crucial role in the suppression of intestinal inflammation. However, their role in the suppression of inflammatory bowel disease has not yet been addressed. We examined the proportion of regulatory T cells in inflammatory bowel disease. First, we isolated CD4+CD45RO+CD25+ T cells from the peripheral blood of healthy persons and showed that these cells suppressed T cell proliferation profoundly and expressed FoxP3 abundantly, revealing that they are regulatory cells. Then the proportion of CD45RO+CD25+ in peripheral blood CD4+ T cells was analyzed in patients and healthy controls by flow cytometry. CD4+CD45RO+CD25+ T cell frequency was significantly lower in active ulcerative colitis than in the control and inactive ulcerative colitis. CD4+CD45RO+CD25+ T cell frequency was inversely correlated with the clinical and endoscopic severity of ulcerative colitis. These results suggest that a deficiency of regulatory T cells is associated with the progression of ulcerative colitis.

本文言語英語
ページ(範囲)677-686
ページ数10
ジャーナルDigestive Diseases and Sciences
51
4
DOI
出版ステータス出版済み - 4 2006

All Science Journal Classification (ASJC) codes

  • 生理学
  • 消化器病学

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