6 Conclusions: This study demonstrates the potential of SPG as an oligonucleotide carrier, for example, in antisense and CpG DNAs. The most distinguishing feature of this carrier compared to other cation types is that the driving force of the complexation is hydrogen bonds instead of electrostatic forces. Therefore, the total charge of the SPG/nucleotide complex is negative and there is no DNA-compaction problem in this system. Using chemically modified SPG, the antisense effect and CpG immunostimulatory response can be enhanced.
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