An oligonucleotide carrier based on β-1,3-glucans

Kazuo Sakurai, Seiji Shinkai

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

6 Conclusions: This study demonstrates the potential of SPG as an oligonucleotide carrier, for example, in antisense and CpG DNAs. The most distinguishing feature of this carrier compared to other cation types is that the driving force of the complexation is hydrogen bonds instead of electrostatic forces. Therefore, the total charge of the SPG/nucleotide complex is negative and there is no DNA-compaction problem in this system. Using chemically modified SPG, the antisense effect and CpG immunostimulatory response can be enhanced.

本文言語英語
ホスト出版物のタイトルNon-viral Gene Therapy
ホスト出版物のサブタイトルGene Design and Delivery
出版社Springer-Verlag Tokyo
ページ103-117
ページ数15
ISBN(電子版)9784431278795
ISBN(印刷版)4431251227, 9784431251224
DOI
出版ステータス出版済み - 1 1 2005

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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