An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling

Scott Erickson, Hiroki Ihara, Sanshiro Hanada, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.

本文言語英語
ホスト出版物のタイトル33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
出版社Institute of Electrical and Electronics Engineers Inc.
ページ444-447
ページ数4
ISBN(電子版)9781728135809
DOI
出版ステータス出版済み - 1 2020
イベント33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, カナダ
継続期間: 1 18 20201 22 2020

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
2020-January
ISSN(印刷版)1084-6999

会議

会議33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
国/地域カナダ
CityVancouver
Period1/18/201/22/20

All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 機械工学
  • 電子工学および電気工学

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