Analysis for effect of cell shape on hippo signaling pathway using micro-fabricated cell culture platform

Ken Ichi Wada, Kazuyoshi Itoga, Teruo Okano, Shigenobu Yonemura, Hiroshi Sasaki

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Cell density affects Hippo signals, which regulates cell proliferation, but its molecular mechanism is still unclear. In this study, we examined the effect of cell shape on Hippo pathway by using micro fabricated cell culture platform and found that F-actin formation was modulated by cell shapes and F-actin had an inhibitory effect on Hippo pathway. This findings suggest that cell shape is an important factor in the regulation of cell proliferation via Hippo signaling, and that cells can detect density through their resulting morphology by F-actin mediated mechanism to regulate proliferation.

本文言語英語
ホスト出版物のタイトルProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社Chemical and Biological Microsystems Society
ページ1051-1053
ページ数3
ISBN(印刷版)9780979806452
出版ステータス出版済み - 2012
外部発表はい
イベント16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, 日本
継続期間: 10 28 201211 1 2012

出版物シリーズ

名前Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

その他

その他16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
国/地域日本
CityOkinawa
Period10/28/1211/1/12

All Science Journal Classification (ASJC) codes

  • 化学工学(その他)
  • バイオエンジニアリング

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