TY - JOUR
T1 - Analysis of class II genes of human leukocyte antigen in patients with Moyamoya disease
AU - Inoue, Takuya K.
AU - Ikezaki, Kiyonobu
AU - Sasazuki, Takehiko
AU - Matsushima, Toshio
AU - Fukui, Masashi
N1 - Funding Information:
Dr Ikezaki, Dr Fukui and Dr Sasazuki were supported by grants from the Ministry of Health and Welfare, Japan. We thank the following doctors who kindly cooperated for collecting samples, Dr Yoshiharu Sakurai (Sendai National Hospital), Prof. Hiroshi Yamada (Gifu University School of Medicine), Prof. Kazuo Yamada (Medical School, Nagoya City University), Prof. Toru Hayakawa (Osaka University, Medical School), Prof. Satoshi Ueda (Kyoto Prefectural University of Medicine), Prof. Takashi Oomoto (Okayama University, Medical School).
PY - 1997/10
Y1 - 1997/10
N2 - Moyamoya disease is a progressive stenoocclusive disease at the terminal portion of the bilateral internal carotid arteries. An unusual Vascular network is formed as a result of ishemic change of cerebrovascular system. Although some investigations suggested possible etiological factors of Moyamoya disease, the etiology is still unknown. To elucidate the genetic factors of Moyamoya disease, class II genes of human leukocyte antigen (HLA) were analyzed at the DNA level. The DNA typing of HLA was performed in the unrelated Japanese patients with definite Moyamoya disease using extracted genomic DNA from the leukocyte. The genotype was confirmed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) technique. The class II genotypes were analyzed in 71 samples. As a result, several alleles of class II genes showed significant association with Moyamoya disease. DQB1*0502 had positive association with the disease. On the other hand DRB1*0405 and DQB1*0401 had negative association. Moyamoya disease seems to have a genetic background in its etiology because certain alleles of HLA are associated with Moyamoya disease.
AB - Moyamoya disease is a progressive stenoocclusive disease at the terminal portion of the bilateral internal carotid arteries. An unusual Vascular network is formed as a result of ishemic change of cerebrovascular system. Although some investigations suggested possible etiological factors of Moyamoya disease, the etiology is still unknown. To elucidate the genetic factors of Moyamoya disease, class II genes of human leukocyte antigen (HLA) were analyzed at the DNA level. The DNA typing of HLA was performed in the unrelated Japanese patients with definite Moyamoya disease using extracted genomic DNA from the leukocyte. The genotype was confirmed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) technique. The class II genotypes were analyzed in 71 samples. As a result, several alleles of class II genes showed significant association with Moyamoya disease. DQB1*0502 had positive association with the disease. On the other hand DRB1*0405 and DQB1*0401 had negative association. Moyamoya disease seems to have a genetic background in its etiology because certain alleles of HLA are associated with Moyamoya disease.
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U2 - 10.1016/s0303-8467(97)00051-6
DO - 10.1016/s0303-8467(97)00051-6
M3 - Article
C2 - 9409445
AN - SCOPUS:0030670561
SN - 0303-8467
VL - 99
SP - S234-S237
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - SUPPL. 2
ER -
