Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis

A multi-institutional study

Shin Nishio, Yoshiki Mikami, Hideki Tokunaga, Nobuo Yaegashi, Toyomi Satoh, Motoaki Saito, Aikou Okamoto, Takahiro Kasamatsu, Tsutomu Miyamoto, Tanri Shiozawa, Yumiko Yoshioka, Masaki Mandai, Atsumi Kojima, Kazuhiro Takehara, Kaneki Eisuke, Hiroaki Kobayashi, Tsunehisa Kaku, Kimio Ushijima, Toshiharu Kamura

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients. Methods: Patients were enrolled by the Gynecologic Cancer Study Group of the Japan Clinical Oncology Group after receiving the approval of each Institutional Review Board. The study population comprised of women with stage I to II endocervical adenocarcinomas who underwent surgery between 2000 and 2009. Representative slides were evaluated by central pathological review (CPR), categorized into either GAS or UEA, and correlated with clinicopathological features and outcome. Results: Among the 393 enrolled patients with endocervical adenocarcinoma, 328 patients met the criteria for CPR and the study eligibility criteria and were included in further analysis. A total of 95 of the 328 tumors were classified as GAS. Compared with UEA, GAS was more significantly associated with bulky mass, deep stromal invasion, lymphovascular space invasion, parametrial invasion, ovarian metastasis, positive ascitic fluid cytology, pelvic lymph node metastasis, and pathological (p) T stage but was not related to the degree of histological differentiation. Disease-free survival (P < 0.0001) and overall survival (P < 0.0001) were poorer in patients with GAS than in those with UEA. Conclusions: GAS showed aggressive behavior with ominous histopathological predictors as well as decreased survival. GAS is therefore considered a distinct entity that should be distinguished from UEA. Clinical trial information: UMIN Clinical Trials Registry: UMIN000007987

元の言語英語
ページ(範囲)13-19
ページ数7
ジャーナルGynecologic Oncology
153
発行部数1
DOI
出版物ステータス出版済み - 4 1 2019

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Mucinous Adenocarcinoma
Cervix Uteri
Stomach
Adenocarcinoma
Neoplasms
Clinical Trials
Neoplasm Metastasis
Survival
Medical Oncology
Ascitic Fluid
Research Ethics Committees
Disease-Free Survival
Cell Biology
Registries
Japan
Lymph Nodes
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

これを引用

Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis : A multi-institutional study. / Nishio, Shin; Mikami, Yoshiki; Tokunaga, Hideki; Yaegashi, Nobuo; Satoh, Toyomi; Saito, Motoaki; Okamoto, Aikou; Kasamatsu, Takahiro; Miyamoto, Tsutomu; Shiozawa, Tanri; Yoshioka, Yumiko; Mandai, Masaki; Kojima, Atsumi; Takehara, Kazuhiro; Eisuke, Kaneki; Kobayashi, Hiroaki; Kaku, Tsunehisa; Ushijima, Kimio; Kamura, Toshiharu.

:: Gynecologic Oncology, 巻 153, 番号 1, 01.04.2019, p. 13-19.

研究成果: ジャーナルへの寄稿記事

Nishio, S, Mikami, Y, Tokunaga, H, Yaegashi, N, Satoh, T, Saito, M, Okamoto, A, Kasamatsu, T, Miyamoto, T, Shiozawa, T, Yoshioka, Y, Mandai, M, Kojima, A, Takehara, K, Eisuke, K, Kobayashi, H, Kaku, T, Ushijima, K & Kamura, T 2019, 'Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis: A multi-institutional study', Gynecologic Oncology, 巻. 153, 番号 1, pp. 13-19. https://doi.org/10.1016/j.ygyno.2019.01.022
Nishio, Shin ; Mikami, Yoshiki ; Tokunaga, Hideki ; Yaegashi, Nobuo ; Satoh, Toyomi ; Saito, Motoaki ; Okamoto, Aikou ; Kasamatsu, Takahiro ; Miyamoto, Tsutomu ; Shiozawa, Tanri ; Yoshioka, Yumiko ; Mandai, Masaki ; Kojima, Atsumi ; Takehara, Kazuhiro ; Eisuke, Kaneki ; Kobayashi, Hiroaki ; Kaku, Tsunehisa ; Ushijima, Kimio ; Kamura, Toshiharu. / Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis : A multi-institutional study. :: Gynecologic Oncology. 2019 ; 巻 153, 番号 1. pp. 13-19.
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abstract = "Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients. Methods: Patients were enrolled by the Gynecologic Cancer Study Group of the Japan Clinical Oncology Group after receiving the approval of each Institutional Review Board. The study population comprised of women with stage I to II endocervical adenocarcinomas who underwent surgery between 2000 and 2009. Representative slides were evaluated by central pathological review (CPR), categorized into either GAS or UEA, and correlated with clinicopathological features and outcome. Results: Among the 393 enrolled patients with endocervical adenocarcinoma, 328 patients met the criteria for CPR and the study eligibility criteria and were included in further analysis. A total of 95 of the 328 tumors were classified as GAS. Compared with UEA, GAS was more significantly associated with bulky mass, deep stromal invasion, lymphovascular space invasion, parametrial invasion, ovarian metastasis, positive ascitic fluid cytology, pelvic lymph node metastasis, and pathological (p) T stage but was not related to the degree of histological differentiation. Disease-free survival (P < 0.0001) and overall survival (P < 0.0001) were poorer in patients with GAS than in those with UEA. Conclusions: GAS showed aggressive behavior with ominous histopathological predictors as well as decreased survival. GAS is therefore considered a distinct entity that should be distinguished from UEA. Clinical trial information: UMIN Clinical Trials Registry: UMIN000007987",
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T1 - Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis

T2 - A multi-institutional study

AU - Nishio, Shin

AU - Mikami, Yoshiki

AU - Tokunaga, Hideki

AU - Yaegashi, Nobuo

AU - Satoh, Toyomi

AU - Saito, Motoaki

AU - Okamoto, Aikou

AU - Kasamatsu, Takahiro

AU - Miyamoto, Tsutomu

AU - Shiozawa, Tanri

AU - Yoshioka, Yumiko

AU - Mandai, Masaki

AU - Kojima, Atsumi

AU - Takehara, Kazuhiro

AU - Eisuke, Kaneki

AU - Kobayashi, Hiroaki

AU - Kaku, Tsunehisa

AU - Ushijima, Kimio

AU - Kamura, Toshiharu

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients. Methods: Patients were enrolled by the Gynecologic Cancer Study Group of the Japan Clinical Oncology Group after receiving the approval of each Institutional Review Board. The study population comprised of women with stage I to II endocervical adenocarcinomas who underwent surgery between 2000 and 2009. Representative slides were evaluated by central pathological review (CPR), categorized into either GAS or UEA, and correlated with clinicopathological features and outcome. Results: Among the 393 enrolled patients with endocervical adenocarcinoma, 328 patients met the criteria for CPR and the study eligibility criteria and were included in further analysis. A total of 95 of the 328 tumors were classified as GAS. Compared with UEA, GAS was more significantly associated with bulky mass, deep stromal invasion, lymphovascular space invasion, parametrial invasion, ovarian metastasis, positive ascitic fluid cytology, pelvic lymph node metastasis, and pathological (p) T stage but was not related to the degree of histological differentiation. Disease-free survival (P < 0.0001) and overall survival (P < 0.0001) were poorer in patients with GAS than in those with UEA. Conclusions: GAS showed aggressive behavior with ominous histopathological predictors as well as decreased survival. GAS is therefore considered a distinct entity that should be distinguished from UEA. Clinical trial information: UMIN Clinical Trials Registry: UMIN000007987

AB - Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients. Methods: Patients were enrolled by the Gynecologic Cancer Study Group of the Japan Clinical Oncology Group after receiving the approval of each Institutional Review Board. The study population comprised of women with stage I to II endocervical adenocarcinomas who underwent surgery between 2000 and 2009. Representative slides were evaluated by central pathological review (CPR), categorized into either GAS or UEA, and correlated with clinicopathological features and outcome. Results: Among the 393 enrolled patients with endocervical adenocarcinoma, 328 patients met the criteria for CPR and the study eligibility criteria and were included in further analysis. A total of 95 of the 328 tumors were classified as GAS. Compared with UEA, GAS was more significantly associated with bulky mass, deep stromal invasion, lymphovascular space invasion, parametrial invasion, ovarian metastasis, positive ascitic fluid cytology, pelvic lymph node metastasis, and pathological (p) T stage but was not related to the degree of histological differentiation. Disease-free survival (P < 0.0001) and overall survival (P < 0.0001) were poorer in patients with GAS than in those with UEA. Conclusions: GAS showed aggressive behavior with ominous histopathological predictors as well as decreased survival. GAS is therefore considered a distinct entity that should be distinguished from UEA. Clinical trial information: UMIN Clinical Trials Registry: UMIN000007987

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