Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production

Kosuke Tsutsumi, Ohtsuka Takao, Yasuhisa Mori, Minoru Fujino, Takaharu Yasui, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Tetsuhide Ito, Masao Tanaka

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

抄録

Background Because of the rarity and variety of pancreatic neuroendocrine tumors (PNETs), there have been few reports regarding the indication for lymph node dissection in patients with these tumors. This study aimed to evaluate the risk of lymph node metastasis of PNETs based on the tumor size and hormonal production. Methods Data for a total of 66 patients who had PNETs resected at our department between 1987 and 2010 were retrospectively studied. The clinicopathological features, including the disease-specific survival rate, were assessed based on the status of lymph node metastasis at the time of initial surgical resection. Then the cut-off point of tumor size to predict lymph node metastasis was estimated. Results There were 12 patients (18%) with lymph node metastasis. The frequency of lymph node metastasis tended to be higher in gastrinomas than that in other tumors (43 vs. 15%; P = 0.08). The size of PNETs with lymph node metastasis was significantly larger than that of the PNETs without metastasis (P = 0.04). The postoperative survival rate in the PNET patients with lymph node metastasis was significantly lower than that in the patients without metastasis (P<0.0001). Only 2 (8%) of 26 PNETs with a tumor size of <15 mm had lymph node metastasis, and both of these were gastrinomas. On the other hand, 10 (25%) of the remaining 40 PNETs with a tumor size of C15 mm had lymph node metastasis. Notably, there were no PNETs with lymph node metastasis in 22 non-gastrinomas with a tumor size of<15 mm. Conclusions Non-gastrinomas with a tumor size of C15 mm and all gastrinomas would be an indication for pancreatectomy with lymph node dissection.

元の言語英語
ページ(範囲)678-685
ページ数8
ジャーナルJournal of gastroenterology
47
発行部数6
DOI
出版物ステータス出版済み - 6 1 2012

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Neuroendocrine Tumors
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Gastrinoma
Lymph Node Excision
Survival Rate
Pancreatectomy

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production. / Tsutsumi, Kosuke; Takao, Ohtsuka; Mori, Yasuhisa; Fujino, Minoru; Yasui, Takaharu; Aishima, Shinichi; Takahata, Shunichi; Nakamura, Masafumi; Ito, Tetsuhide; Tanaka, Masao.

:: Journal of gastroenterology, 巻 47, 番号 6, 01.06.2012, p. 678-685.

研究成果: ジャーナルへの寄稿記事

Tsutsumi, Kosuke ; Takao, Ohtsuka ; Mori, Yasuhisa ; Fujino, Minoru ; Yasui, Takaharu ; Aishima, Shinichi ; Takahata, Shunichi ; Nakamura, Masafumi ; Ito, Tetsuhide ; Tanaka, Masao. / Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production. :: Journal of gastroenterology. 2012 ; 巻 47, 番号 6. pp. 678-685.
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title = "Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production",
abstract = "Background Because of the rarity and variety of pancreatic neuroendocrine tumors (PNETs), there have been few reports regarding the indication for lymph node dissection in patients with these tumors. This study aimed to evaluate the risk of lymph node metastasis of PNETs based on the tumor size and hormonal production. Methods Data for a total of 66 patients who had PNETs resected at our department between 1987 and 2010 were retrospectively studied. The clinicopathological features, including the disease-specific survival rate, were assessed based on the status of lymph node metastasis at the time of initial surgical resection. Then the cut-off point of tumor size to predict lymph node metastasis was estimated. Results There were 12 patients (18{\%}) with lymph node metastasis. The frequency of lymph node metastasis tended to be higher in gastrinomas than that in other tumors (43 vs. 15{\%}; P = 0.08). The size of PNETs with lymph node metastasis was significantly larger than that of the PNETs without metastasis (P = 0.04). The postoperative survival rate in the PNET patients with lymph node metastasis was significantly lower than that in the patients without metastasis (P<0.0001). Only 2 (8{\%}) of 26 PNETs with a tumor size of <15 mm had lymph node metastasis, and both of these were gastrinomas. On the other hand, 10 (25{\%}) of the remaining 40 PNETs with a tumor size of C15 mm had lymph node metastasis. Notably, there were no PNETs with lymph node metastasis in 22 non-gastrinomas with a tumor size of<15 mm. Conclusions Non-gastrinomas with a tumor size of C15 mm and all gastrinomas would be an indication for pancreatectomy with lymph node dissection.",
author = "Kosuke Tsutsumi and Ohtsuka Takao and Yasuhisa Mori and Minoru Fujino and Takaharu Yasui and Shinichi Aishima and Shunichi Takahata and Masafumi Nakamura and Tetsuhide Ito and Masao Tanaka",
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T1 - Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production

AU - Tsutsumi, Kosuke

AU - Takao, Ohtsuka

AU - Mori, Yasuhisa

AU - Fujino, Minoru

AU - Yasui, Takaharu

AU - Aishima, Shinichi

AU - Takahata, Shunichi

AU - Nakamura, Masafumi

AU - Ito, Tetsuhide

AU - Tanaka, Masao

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background Because of the rarity and variety of pancreatic neuroendocrine tumors (PNETs), there have been few reports regarding the indication for lymph node dissection in patients with these tumors. This study aimed to evaluate the risk of lymph node metastasis of PNETs based on the tumor size and hormonal production. Methods Data for a total of 66 patients who had PNETs resected at our department between 1987 and 2010 were retrospectively studied. The clinicopathological features, including the disease-specific survival rate, were assessed based on the status of lymph node metastasis at the time of initial surgical resection. Then the cut-off point of tumor size to predict lymph node metastasis was estimated. Results There were 12 patients (18%) with lymph node metastasis. The frequency of lymph node metastasis tended to be higher in gastrinomas than that in other tumors (43 vs. 15%; P = 0.08). The size of PNETs with lymph node metastasis was significantly larger than that of the PNETs without metastasis (P = 0.04). The postoperative survival rate in the PNET patients with lymph node metastasis was significantly lower than that in the patients without metastasis (P<0.0001). Only 2 (8%) of 26 PNETs with a tumor size of <15 mm had lymph node metastasis, and both of these were gastrinomas. On the other hand, 10 (25%) of the remaining 40 PNETs with a tumor size of C15 mm had lymph node metastasis. Notably, there were no PNETs with lymph node metastasis in 22 non-gastrinomas with a tumor size of<15 mm. Conclusions Non-gastrinomas with a tumor size of C15 mm and all gastrinomas would be an indication for pancreatectomy with lymph node dissection.

AB - Background Because of the rarity and variety of pancreatic neuroendocrine tumors (PNETs), there have been few reports regarding the indication for lymph node dissection in patients with these tumors. This study aimed to evaluate the risk of lymph node metastasis of PNETs based on the tumor size and hormonal production. Methods Data for a total of 66 patients who had PNETs resected at our department between 1987 and 2010 were retrospectively studied. The clinicopathological features, including the disease-specific survival rate, were assessed based on the status of lymph node metastasis at the time of initial surgical resection. Then the cut-off point of tumor size to predict lymph node metastasis was estimated. Results There were 12 patients (18%) with lymph node metastasis. The frequency of lymph node metastasis tended to be higher in gastrinomas than that in other tumors (43 vs. 15%; P = 0.08). The size of PNETs with lymph node metastasis was significantly larger than that of the PNETs without metastasis (P = 0.04). The postoperative survival rate in the PNET patients with lymph node metastasis was significantly lower than that in the patients without metastasis (P<0.0001). Only 2 (8%) of 26 PNETs with a tumor size of <15 mm had lymph node metastasis, and both of these were gastrinomas. On the other hand, 10 (25%) of the remaining 40 PNETs with a tumor size of C15 mm had lymph node metastasis. Notably, there were no PNETs with lymph node metastasis in 22 non-gastrinomas with a tumor size of<15 mm. Conclusions Non-gastrinomas with a tumor size of C15 mm and all gastrinomas would be an indication for pancreatectomy with lymph node dissection.

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U2 - 10.1007/s00535-012-0540-0

DO - 10.1007/s00535-012-0540-0

M3 - Article

VL - 47

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EP - 685

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

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