Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury

Miho Irie, Eisuke Hayakawa, Yoshinori Fujimura, Youhei Honda, Daiki Setoyama, Hiroyuki Wariishi, Fuminori Hyodo, Daisuke Miura

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Clinical application of the major anticancer drug, cisplatin, is limited by severe side effects, especially acute kidney injury (AKI) caused by nephrotoxicity. The detailed metabolic mechanism is still largely unknown. Here, we used an integrated technique combining mass spectrometry imaging (MSI) and liquid chromatography–mass spectrometry (LC–MS) to visualize the diverse spatiotemporal metabolic dynamics in the mouse kidney after cisplatin dosing. Biological responses to cisplatin was more sensitively detected within 24 h as a metabolic alteration, which is much earlier than possible with the conventional clinical chemistry method of blood urea nitrogen (BUN) measurement. Region-specific changes (e.g., medulla and cortex) in metabolites related to DNA damage and energy generation were observed over the 72-h exposure period. Therefore, this metabolomics approach may become a novel strategy for elucidating early renal responses to cisplatin, prior to the detection of kidney damage evaluated by conventional method.

元の言語英語
ページ(範囲)140-146
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
496
発行部数1
DOI
出版物ステータス出版済み - 1 29 2018

Fingerprint

Spatio-Temporal Analysis
Metabolomics
Environmental Monitoring
Acute Kidney Injury
Cisplatin
Monitoring
Kidney
Clinical Chemistry
Blood Urea Nitrogen
Metabolites
Spectrometry
DNA Damage
Mass spectrometry
Urea
Mass Spectrometry
Spectrum Analysis
Blood
Nitrogen
Imaging techniques
DNA

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury. / Irie, Miho; Hayakawa, Eisuke; Fujimura, Yoshinori; Honda, Youhei; Setoyama, Daiki; Wariishi, Hiroyuki; Hyodo, Fuminori; Miura, Daisuke.

:: Biochemical and Biophysical Research Communications, 巻 496, 番号 1, 29.01.2018, p. 140-146.

研究成果: ジャーナルへの寄稿記事

Irie, Miho ; Hayakawa, Eisuke ; Fujimura, Yoshinori ; Honda, Youhei ; Setoyama, Daiki ; Wariishi, Hiroyuki ; Hyodo, Fuminori ; Miura, Daisuke. / Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury. :: Biochemical and Biophysical Research Communications. 2018 ; 巻 496, 番号 1. pp. 140-146.
@article{85fabe5f64964fd1948a01b28d04590e,
title = "Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury",
abstract = "Clinical application of the major anticancer drug, cisplatin, is limited by severe side effects, especially acute kidney injury (AKI) caused by nephrotoxicity. The detailed metabolic mechanism is still largely unknown. Here, we used an integrated technique combining mass spectrometry imaging (MSI) and liquid chromatography–mass spectrometry (LC–MS) to visualize the diverse spatiotemporal metabolic dynamics in the mouse kidney after cisplatin dosing. Biological responses to cisplatin was more sensitively detected within 24 h as a metabolic alteration, which is much earlier than possible with the conventional clinical chemistry method of blood urea nitrogen (BUN) measurement. Region-specific changes (e.g., medulla and cortex) in metabolites related to DNA damage and energy generation were observed over the 72-h exposure period. Therefore, this metabolomics approach may become a novel strategy for elucidating early renal responses to cisplatin, prior to the detection of kidney damage evaluated by conventional method.",
author = "Miho Irie and Eisuke Hayakawa and Yoshinori Fujimura and Youhei Honda and Daiki Setoyama and Hiroyuki Wariishi and Fuminori Hyodo and Daisuke Miura",
year = "2018",
month = "1",
day = "29",
doi = "10.1016/j.bbrc.2018.01.012",
language = "English",
volume = "496",
pages = "140--146",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury

AU - Irie, Miho

AU - Hayakawa, Eisuke

AU - Fujimura, Yoshinori

AU - Honda, Youhei

AU - Setoyama, Daiki

AU - Wariishi, Hiroyuki

AU - Hyodo, Fuminori

AU - Miura, Daisuke

PY - 2018/1/29

Y1 - 2018/1/29

N2 - Clinical application of the major anticancer drug, cisplatin, is limited by severe side effects, especially acute kidney injury (AKI) caused by nephrotoxicity. The detailed metabolic mechanism is still largely unknown. Here, we used an integrated technique combining mass spectrometry imaging (MSI) and liquid chromatography–mass spectrometry (LC–MS) to visualize the diverse spatiotemporal metabolic dynamics in the mouse kidney after cisplatin dosing. Biological responses to cisplatin was more sensitively detected within 24 h as a metabolic alteration, which is much earlier than possible with the conventional clinical chemistry method of blood urea nitrogen (BUN) measurement. Region-specific changes (e.g., medulla and cortex) in metabolites related to DNA damage and energy generation were observed over the 72-h exposure period. Therefore, this metabolomics approach may become a novel strategy for elucidating early renal responses to cisplatin, prior to the detection of kidney damage evaluated by conventional method.

AB - Clinical application of the major anticancer drug, cisplatin, is limited by severe side effects, especially acute kidney injury (AKI) caused by nephrotoxicity. The detailed metabolic mechanism is still largely unknown. Here, we used an integrated technique combining mass spectrometry imaging (MSI) and liquid chromatography–mass spectrometry (LC–MS) to visualize the diverse spatiotemporal metabolic dynamics in the mouse kidney after cisplatin dosing. Biological responses to cisplatin was more sensitively detected within 24 h as a metabolic alteration, which is much earlier than possible with the conventional clinical chemistry method of blood urea nitrogen (BUN) measurement. Region-specific changes (e.g., medulla and cortex) in metabolites related to DNA damage and energy generation were observed over the 72-h exposure period. Therefore, this metabolomics approach may become a novel strategy for elucidating early renal responses to cisplatin, prior to the detection of kidney damage evaluated by conventional method.

UR - http://www.scopus.com/inward/record.url?scp=85040370974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040370974&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2018.01.012

DO - 10.1016/j.bbrc.2018.01.012

M3 - Article

C2 - 29307833

AN - SCOPUS:85040370974

VL - 496

SP - 140

EP - 146

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -