TY - JOUR
T1 - Analysis of Stereochemical Stability of Dynamic Chiral Molecules Using an Automated Microflow Measurement System
AU - Igawa, Kazunobu
AU - Asano, Shusaku
AU - Yoshida, Yuki
AU - Kawasaki, Yuuya
AU - Tomooka, Katsuhiko
N1 - Funding Information:
This research was supported by JSPS KAKENHI grants (20H02743, 20H05677, 20K15081) and the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”. This work was carried out using the research equipment shared in the MEXT Project for promoting the public utilization of advanced research infrastructure (Program for supporting the introduction of the new sharing system), Grant No. JPMXS0422300120. The authors thank Yukiko Irie for her technical assistance.
Publisher Copyright:
©
PY - 2021/7/16
Y1 - 2021/7/16
N2 - An automated microflow measurement system for the kinetic study of racemization of dynamic chiral molecules was developed. This system facilitated the analysis of fast racemization within several seconds at elevated temperatures owing to its rapid heating ability, high performance for controlling short residence times, and ease of connection to HPLC systems for direct measurement of the enantiomeric purity. A more precise analysis was realized by combination of microflow and common batch measurements over a broad range of temperatures.
AB - An automated microflow measurement system for the kinetic study of racemization of dynamic chiral molecules was developed. This system facilitated the analysis of fast racemization within several seconds at elevated temperatures owing to its rapid heating ability, high performance for controlling short residence times, and ease of connection to HPLC systems for direct measurement of the enantiomeric purity. A more precise analysis was realized by combination of microflow and common batch measurements over a broad range of temperatures.
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U2 - 10.1021/acs.joc.1c00914
DO - 10.1021/acs.joc.1c00914
M3 - Article
AN - SCOPUS:85110974891
VL - 86
SP - 9651
EP - 9657
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 14
ER -