Analysis of the mechanism of allograft rejection and cell-mediated immunity. I. Accelerated rejection of tumour allografts without augmented cytotoxicity in the spleen cells

F. Nanishi, K. Nomoto, K. Taniguchi, C. Kubo

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

While immunization with allogeneic spleen cells did not generate positive cytotoxic activity, it produced accelerated rejection of subsequent tumour grafts carrying the same H-2 antigen. No augmented generation of cytotoxicity was detectable by 51Cr release assay in the host spleen cells, even in the presence of accelerated rejection of tumour allografts. However, augmented cytotoxicity was generated in mixed lymphocyte culture and in peritoneal lymphocytes after an intraperitoneal boost. These results indicate that while immunization with allogeneic spleen cells does generate mature cytotoxic T lymphocytes (CTL) detectable by the present assay, it may produce premature CTL that rapidly differentiate into mature CTL after direct contact with antigen at the site of graft rejection. The inability to generate a high degree of cytotoxicity in the spleen cells may be ascribed to the early development of CTL at the rejection site. The relationship between accelerated rejection of allogeneic tumour grafts and delayed-type hypersensitivity reactions is also discussed.

本文言語英語
ページ(範囲)67-76
ページ数10
ジャーナルImmunology
40
1
出版ステータス出版済み - 1980
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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