Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen

K. Honda, K. Makishima, T. Sasazuki

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Genetic control of the immune response to Cryptomeria japonica pollen antigen (CPAg) in humans was analyzed using 72 unrelated healthy adults. The 72 were classified into a low responder group and a high responder group by using purified CPAg. Significant associations were found between IgG low responsiveness to purified CPAg and possession of HLA-DQw3. Relative risks for the two groups were 4.80. Peripheral blood lymphocytes from low responders revealed a specific IgG response to CPAg when the CD8+ T cell fraction was depleted. Thereby, low response due to the presence of CPAg-specific CD8+ suppressor T cells was suggested.

本文言語英語
ページ(範囲)423-427
ページ数5
ジャーナルArerugī = [Allergy]
40
4
出版ステータス出版済み - 4 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学

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