Androgen insensitivity syndrome and co-activator disease

Androgen insensitivity syndrome(AIS) is a clinical continuum of virilization disorders in XY males. Almost AIS is due to mutations in androgen receptor(AR) gene. Over 300 mutations in the AR gene have been reported. In addition, we have reported the case of complete AIS who has no mutations in AR gene, caused by co-activator abnormality. The recent advances in live-cell imaging techniques have developed a novel concept in AIS.