Androgen receptor cofactors in prostate cancer: Potential therapeutic targets of castration-resistant prostate cancer

Masaki Shiota, Akira Yokomizo, Naohiro Fujimoto, Seiji Naito

研究成果: Contribution to journalReview article査読

35 被引用数 (Scopus)

抄録

Androgens, acting through the androgen receptor (AR), are responsible for many male reproductive and nonreproductive functions. Moreover, aberrant androgen/AR signaling plays a critical role in androgen-dependent prostate cancer (PCa) as well as castration-resistant prostate cancer (CRPC). The formation of a productive AR transcriptional complex requires AR cofactors that interact functionally and structurally with the AR. Since the discovery of the first such cofactor in 1995, an ever increasing number of proteins have been identified as AR coactivators or corepressors. The expression and function of several AR cofactors have been investigated in PCa, and a clear link between AR cofactors and the development and progression of PCa has been identified. Recently, AR splice variants in CRPC were reported, which display significant constitutive activity in the absence of ligand. Then, this discovery revolutionized the concept of AR cofactors in CRPC. The current review aims to provide an overview of AR cofactor proteins in the context of PCa. In addition, we discuss the potential of AR cofactors as novel therapeutic targets for PCa, particularly for CRPC.

本文言語英語
ページ(範囲)870-881
ページ数12
ジャーナルCurrent Cancer Drug Targets
11
7
DOI
出版ステータス出版済み - 9 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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