Anemia in Patients with Severe Aortic Stenosis

CURRENT AS Registry Investigators

研究成果: ジャーナルへの寄稿記事

抄録

Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38%) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95% confidence interval (CI): 1.07–1.57 and HR: 1.56; 95%CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95%CI: 1.40–2.13 and HR: 2.05; 95%CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95%CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95%CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes.

元の言語英語
記事番号1924
ジャーナルScientific reports
9
発行部数1
DOI
出版物ステータス出版済み - 12 1 2019

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Aortic Valve Stenosis
Anemia
Confidence Intervals
Aortic Valve
Hemoglobins
Outcome Assessment (Health Care)
Hemorrhage
Registries
Hospitalization
Heart Failure
Population

All Science Journal Classification (ASJC) codes

  • General

これを引用

Anemia in Patients with Severe Aortic Stenosis. / CURRENT AS Registry Investigators.

:: Scientific reports, 巻 9, 番号 1, 1924, 01.12.2019.

研究成果: ジャーナルへの寄稿記事

CURRENT AS Registry Investigators. / Anemia in Patients with Severe Aortic Stenosis. :: Scientific reports. 2019 ; 巻 9, 番号 1.
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title = "Anemia in Patients with Severe Aortic Stenosis",
abstract = "Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25{\%}) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38{\%}) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95{\%} confidence interval (CI): 1.07–1.57 and HR: 1.56; 95{\%}CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95{\%}CI: 1.40–2.13 and HR: 2.05; 95{\%}CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95{\%}CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95{\%}CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes.",
author = "{CURRENT AS Registry Investigators} and Kazuya Nagao and Tomohiko Taniguchi and Takeshi Morimoto and Hiroki Shiomi and Kenji Ando and Norio Kanamori and Koichiro Murata and Takeshi Kitai and Yuichi Kawase and Chisato Izumi and Makoto Miyake and Hirokazu Mitsuoka and Masashi Kato and Yutaka Hirano and Shintaro Matsuda and Tsukasa Inada and Tomoyuki Murakami and Yasuyo Takeuchi and Keiichiro Yamane and Mamoru Toyofuku and Mitsuru Ishii and Eri Minamino-Muta and Takao Kato and Moriaki Inoko and Tomoyuki Ikeda and Akihiro Komasa and Katsuhisa Ishii and Kozo Hotta and Nobuya Higashitani and Yoshihiro Kato and Yasutaka Inuzuka and Chiyo Maeda and Toshikazu Jinnai and Yuko Morikami and Naritatsu Saito and Kenji Minatoya and Takeshi Kimura and Naoki Takahashi and Kohei Fukuchi and Masao Imai and Junichi Tazaki and Toshiaki Toyota and Hirooki Higami and Tetsuma Kawaji and Shinichi Shirai and Kengo Kourai and Takeshi Arita and Shiro Miura and Takeshi Arita and Tomoya Onodera",
year = "2019",
month = "12",
day = "1",
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T1 - Anemia in Patients with Severe Aortic Stenosis

AU - CURRENT AS Registry Investigators

AU - Nagao, Kazuya

AU - Taniguchi, Tomohiko

AU - Morimoto, Takeshi

AU - Shiomi, Hiroki

AU - Ando, Kenji

AU - Kanamori, Norio

AU - Murata, Koichiro

AU - Kitai, Takeshi

AU - Kawase, Yuichi

AU - Izumi, Chisato

AU - Miyake, Makoto

AU - Mitsuoka, Hirokazu

AU - Kato, Masashi

AU - Hirano, Yutaka

AU - Matsuda, Shintaro

AU - Inada, Tsukasa

AU - Murakami, Tomoyuki

AU - Takeuchi, Yasuyo

AU - Yamane, Keiichiro

AU - Toyofuku, Mamoru

AU - Ishii, Mitsuru

AU - Minamino-Muta, Eri

AU - Kato, Takao

AU - Inoko, Moriaki

AU - Ikeda, Tomoyuki

AU - Komasa, Akihiro

AU - Ishii, Katsuhisa

AU - Hotta, Kozo

AU - Higashitani, Nobuya

AU - Kato, Yoshihiro

AU - Inuzuka, Yasutaka

AU - Maeda, Chiyo

AU - Jinnai, Toshikazu

AU - Morikami, Yuko

AU - Saito, Naritatsu

AU - Minatoya, Kenji

AU - Kimura, Takeshi

AU - Takahashi, Naoki

AU - Fukuchi, Kohei

AU - Imai, Masao

AU - Tazaki, Junichi

AU - Toyota, Toshiaki

AU - Higami, Hirooki

AU - Kawaji, Tetsuma

AU - Shirai, Shinichi

AU - Kourai, Kengo

AU - Arita, Takeshi

AU - Miura, Shiro

AU - Arita, Takeshi

AU - Onodera, Tomoya

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38%) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95% confidence interval (CI): 1.07–1.57 and HR: 1.56; 95%CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95%CI: 1.40–2.13 and HR: 2.05; 95%CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95%CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95%CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes.

AB - Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38%) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95% confidence interval (CI): 1.07–1.57 and HR: 1.56; 95%CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95%CI: 1.40–2.13 and HR: 2.05; 95%CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95%CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95%CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes.

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JO - Scientific Reports

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