Angiogenesis derived from shear stress optimised by a microfruidic device

Yukako Teraoka, Masamune Nakayama, Yuji Nashimoto, Akiko Nakamasu, Sanshiro Hanada, Yuichiro Arima, Yu Suke Torisawa, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.

本文言語英語
ホスト出版物のタイトル21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
出版社Chemical and Biological Microsystems Society
ページ1072-1073
ページ数2
ISBN(電子版)9780692941836
出版ステータス出版済み - 2020
イベント21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, 米国
継続期間: 10 22 201710 26 2017

出版物シリーズ

名前21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

会議

会議21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
国/地域米国
CitySavannah
Period10/22/1710/26/17

All Science Journal Classification (ASJC) codes

  • 化学工学(その他)
  • バイオエンジニアリング

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