Angiogenic and lymphangiogenic cascades in the tumor microenvironment

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)


Blood and lymphatic vessels in tumor tissue are major components of the tumor microenvironment. These vessels are newly formed from pre-existing host vessels stimulated by pro-blood-angiogenic and pro-lymphangiogenic (pro-blood/lymph-angiogenic) factors expressed in tumor cells. Tumor cells establish a specific stromal microenvironment fostering tumor growth, in which blood/lymph-angiogenesis are involved. The tumorassociated blood/lymph- angiogenesis is continually induced by complicated cytokine networks, namely problood/ lymph-angiogenic factor-mediated paracrine and autocrine interactions among tumor cells and stromal cells including endothelial cells (ECs) and non-endothelial mesenchymal cells (neMCs). In this review, we provide an overview of the features of tumor-associated blood/lymphangiogenesis based on recent and updated information obtained mainly from our studies. With regard to the constituent cell-dependent molecular mechanisms that regulate tumor blood/lymph-angiogenesis, we focus on: 1) the role of blood/lymph-angiogenesis- related factors/receptors expressed in tumor cells; and 2) the role of blood/lymph-angiogenesis-related factors/receptors expressed in stromal cells (ECs and neMCs). Finally, we discuss the features of tumor-associated blood/lymphanigogenesis, especially a vessel abnormality through the viewpoint of blood/lymph-angiogenic cascades in tumor microenvironment for better understanding of the tumor vascular biology.

ジャーナルFrontiers in Bioscience - Scholar
3 S
出版ステータス出版済み - 1 1 2011

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)


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