Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: The hisayama study

Hideki Kondo, Toshiharu Ninomiya, Jun Hata, Yoichiro Hirakawa, Koji Yonemoto, Hisatomi Arima, Masaharu Nagata, Kazuhiko Tsuruya, Takanari Kitazono, Yutaka Kiyohara

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Aim: The angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism has been reported to be implicated in susceptibility to coronary heart disease (CHD). However, this association remains inconclusive. The purpose of this study was to clarify the association between the I/D polymorphism of the ACE gene and the development of CHD in a Japanese general population and investigate whether the effects of traditional risk factors on the risk of CHD are heterogeneous among ACE genotypes. Methods: The subjects included 2,125 community-dwelling individuals 40 years of age or older without cardiovascular disease for whom genetic information was available. All patients were prospectively followed for 19 years, and the association between the ACE polymorphism and the incidence of CHD was examined based on the interactions with traditional risk factors, such as hypercholesterolemia, hypertension, diabetes and smoking. Results: A total of 161 CHD events occurred during the follow-up period. The age- and sex-adjusted incidence of CHD was not significantly different among the genotypes (5.8, 5.2, and 6.9 per 1,000 person-years for genotypes II, ID and DD, respectively). In a stratified analysis, however, the ACE DD genotype was found to significantly accelerate the risk of developing CHD by hypercholesterolemia (hazard ratio [HR]=4.50, 95% confidence interval =2.02-10.04 for hypercholesterolemia with the DD genotype; HR=1.48, 95% CI=1.04-2.12 for hypercholesterolemia with the ID+II genotype; P for interaction = 0.01), even after adjusting for other confounding factors, whereas no such associations were observed for hypertension, diabetes or smoking. Conclusions: The current findings suggest that the ACE DD genotype enhances the effect of hypercholesterolemia on the development of CHD in the general Japanese population.

本文言語英語
ページ(範囲)390-403
ページ数14
ジャーナルJournal of atherosclerosis and thrombosis
22
4
DOI
出版ステータス出版済み - 2014

All Science Journal Classification (ASJC) codes

  • 内科学
  • 循環器および心血管医学
  • 生化学、医学

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