Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: The Hisayama Study

Hisatomi Arima, Yutaka Kiyohara, Yumihiro Tanizaki, Yusaku Nakabeppu, Michiaki Kubo, Isao Kato, Katsuo Sueishi, Masazumi Tsuneyoshi, Masatoshi Fujishima, Mitsuo Iida

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

We examined the long-term contribution of smoking and angiotensin I-converting enzyme (ACE) gene I/D polymorphism to total cancer deaths in a prospective study of a general Japanese population. A total of 937 subjects aged 40 years or older were selected from an original cohort of 1621 subjects and were followed up for 32 years. During the follow-up period, 176 subjects died of cancer. Cancer mortality increased significantly with increasing current smoking levels. Although no clear relationship was observed between ACE genotypes and fatal cancer, the interaction term between current smoking and ACE genotype DD was found to be significant. In stratified analysis by ACE genotype after controlling for age, sex, alcohol intake, body mass index, glucose intolerance, serum total cholesterol and systolic blood pressure, the risk of fatal cancer in currently smoking subjects with genotype DD was twofold greater than that in subjects with genotypes II and ID. Among current smokers, subjects with genotype DD also showed a significantly greater risk of death due to cancer compared with those with genotypes II and ID combined (hazard ratio 1.77; 95% confidence interval 1.04-3.00; P = 0.03). In conclusion, our findings suggest that ACE genotype DD enhances the association between smoking and cancer death in the general population.

元の言語英語
ページ(範囲)196-201
ページ数6
ジャーナルEuropean Journal of Cancer Prevention
15
発行部数3
DOI
出版物ステータス出版済み - 6 1 2006

Fingerprint

Peptidyl-Dipeptidase A
Smoking
Genotype
Genes
Neoplasms
Blood Pressure
Glucose Intolerance
Population
Body Mass Index
Cholesterol
Alcohols
Prospective Studies
Confidence Intervals
Mortality
Serum

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

これを引用

Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association : The Hisayama Study. / Arima, Hisatomi; Kiyohara, Yutaka; Tanizaki, Yumihiro; Nakabeppu, Yusaku; Kubo, Michiaki; Kato, Isao; Sueishi, Katsuo; Tsuneyoshi, Masazumi; Fujishima, Masatoshi; Iida, Mitsuo.

:: European Journal of Cancer Prevention, 巻 15, 番号 3, 01.06.2006, p. 196-201.

研究成果: ジャーナルへの寄稿記事

Arima, H, Kiyohara, Y, Tanizaki, Y, Nakabeppu, Y, Kubo, M, Kato, I, Sueishi, K, Tsuneyoshi, M, Fujishima, M & Iida, M 2006, 'Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: The Hisayama Study', European Journal of Cancer Prevention, 巻. 15, 番号 3, pp. 196-201. https://doi.org/10.1097/01.cej.0000199506.15571.37
Arima, Hisatomi ; Kiyohara, Yutaka ; Tanizaki, Yumihiro ; Nakabeppu, Yusaku ; Kubo, Michiaki ; Kato, Isao ; Sueishi, Katsuo ; Tsuneyoshi, Masazumi ; Fujishima, Masatoshi ; Iida, Mitsuo. / Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association : The Hisayama Study. :: European Journal of Cancer Prevention. 2006 ; 巻 15, 番号 3. pp. 196-201.
@article{d3a8ed97ecb94576985c374ce2a6cbc2,
title = "Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: The Hisayama Study",
abstract = "We examined the long-term contribution of smoking and angiotensin I-converting enzyme (ACE) gene I/D polymorphism to total cancer deaths in a prospective study of a general Japanese population. A total of 937 subjects aged 40 years or older were selected from an original cohort of 1621 subjects and were followed up for 32 years. During the follow-up period, 176 subjects died of cancer. Cancer mortality increased significantly with increasing current smoking levels. Although no clear relationship was observed between ACE genotypes and fatal cancer, the interaction term between current smoking and ACE genotype DD was found to be significant. In stratified analysis by ACE genotype after controlling for age, sex, alcohol intake, body mass index, glucose intolerance, serum total cholesterol and systolic blood pressure, the risk of fatal cancer in currently smoking subjects with genotype DD was twofold greater than that in subjects with genotypes II and ID. Among current smokers, subjects with genotype DD also showed a significantly greater risk of death due to cancer compared with those with genotypes II and ID combined (hazard ratio 1.77; 95{\%} confidence interval 1.04-3.00; P = 0.03). In conclusion, our findings suggest that ACE genotype DD enhances the association between smoking and cancer death in the general population.",
author = "Hisatomi Arima and Yutaka Kiyohara and Yumihiro Tanizaki and Yusaku Nakabeppu and Michiaki Kubo and Isao Kato and Katsuo Sueishi and Masazumi Tsuneyoshi and Masatoshi Fujishima and Mitsuo Iida",
year = "2006",
month = "6",
day = "1",
doi = "10.1097/01.cej.0000199506.15571.37",
language = "English",
volume = "15",
pages = "196--201",
journal = "European Journal of Cancer Prevention",
issn = "0959-8278",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association

T2 - The Hisayama Study

AU - Arima, Hisatomi

AU - Kiyohara, Yutaka

AU - Tanizaki, Yumihiro

AU - Nakabeppu, Yusaku

AU - Kubo, Michiaki

AU - Kato, Isao

AU - Sueishi, Katsuo

AU - Tsuneyoshi, Masazumi

AU - Fujishima, Masatoshi

AU - Iida, Mitsuo

PY - 2006/6/1

Y1 - 2006/6/1

N2 - We examined the long-term contribution of smoking and angiotensin I-converting enzyme (ACE) gene I/D polymorphism to total cancer deaths in a prospective study of a general Japanese population. A total of 937 subjects aged 40 years or older were selected from an original cohort of 1621 subjects and were followed up for 32 years. During the follow-up period, 176 subjects died of cancer. Cancer mortality increased significantly with increasing current smoking levels. Although no clear relationship was observed between ACE genotypes and fatal cancer, the interaction term between current smoking and ACE genotype DD was found to be significant. In stratified analysis by ACE genotype after controlling for age, sex, alcohol intake, body mass index, glucose intolerance, serum total cholesterol and systolic blood pressure, the risk of fatal cancer in currently smoking subjects with genotype DD was twofold greater than that in subjects with genotypes II and ID. Among current smokers, subjects with genotype DD also showed a significantly greater risk of death due to cancer compared with those with genotypes II and ID combined (hazard ratio 1.77; 95% confidence interval 1.04-3.00; P = 0.03). In conclusion, our findings suggest that ACE genotype DD enhances the association between smoking and cancer death in the general population.

AB - We examined the long-term contribution of smoking and angiotensin I-converting enzyme (ACE) gene I/D polymorphism to total cancer deaths in a prospective study of a general Japanese population. A total of 937 subjects aged 40 years or older were selected from an original cohort of 1621 subjects and were followed up for 32 years. During the follow-up period, 176 subjects died of cancer. Cancer mortality increased significantly with increasing current smoking levels. Although no clear relationship was observed between ACE genotypes and fatal cancer, the interaction term between current smoking and ACE genotype DD was found to be significant. In stratified analysis by ACE genotype after controlling for age, sex, alcohol intake, body mass index, glucose intolerance, serum total cholesterol and systolic blood pressure, the risk of fatal cancer in currently smoking subjects with genotype DD was twofold greater than that in subjects with genotypes II and ID. Among current smokers, subjects with genotype DD also showed a significantly greater risk of death due to cancer compared with those with genotypes II and ID combined (hazard ratio 1.77; 95% confidence interval 1.04-3.00; P = 0.03). In conclusion, our findings suggest that ACE genotype DD enhances the association between smoking and cancer death in the general population.

UR - http://www.scopus.com/inward/record.url?scp=33646930684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646930684&partnerID=8YFLogxK

U2 - 10.1097/01.cej.0000199506.15571.37

DO - 10.1097/01.cej.0000199506.15571.37

M3 - Article

C2 - 16679861

AN - SCOPUS:33646930684

VL - 15

SP - 196

EP - 201

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

SN - 0959-8278

IS - 3

ER -