Angiotensin II receptor antagonists as the agents to treat cerebrovascular disease

T. Kitazono, M. Fujishima

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Recently, several antagonists of angiotensin II receptors (AII-A) have been developed and are now used as antihypertensive agents. The regional cerebral blood flow appears to show typical changes during the course of cerebral ischemia and AII-A may have a favorable effect on the flow in some situations. Moreover, activation of the renin-angiotensin system plays an important role in the development of cerebrovascular lesions in chronic hypertension. Because several enzymes appear to produce angiotensin II in the absence of classical renin-angiotensin system, it is possible that angiotensin II is produced in some blood vessels even after inhibition of the activity of ACE. Thus, AII-A may be more effective to treat cerebrovascular lesions during hypertension than ACE inhibitors.

元の言語英語
ページ(範囲)1168-1175
ページ数8
ジャーナルNippon rinsho. Japanese journal of clinical medicine
57
発行部数5
出版物ステータス出版済み - 5 1999

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Cerebrovascular Disorders
Angiotensin Receptor Antagonists
Renin-Angiotensin System
Angiotensin II
Cerebrovascular Circulation
Hypertension
Regional Blood Flow
Brain Ischemia
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Blood Vessels
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Angiotensin II receptor antagonists as the agents to treat cerebrovascular disease. / Kitazono, T.; Fujishima, M.

:: Nippon rinsho. Japanese journal of clinical medicine, 巻 57, 番号 5, 05.1999, p. 1168-1175.

研究成果: ジャーナルへの寄稿評論記事

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