Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

A. Tsubura; K. Yoshizawa; M. Kuwata; N. Uehara

Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

A. Tsubura, K. Yoshizawa, M. Kuwata, N. Uehara

研究成果: Contribution to journal › Review article › 査読

抄録

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.

本文言語	英語
ページ（範囲）	933-944
ページ数	12
ジャーナル	Histology and histopathology
巻	25
号	7
出版ステータス	出版済み - 7 2010
外部発表	はい

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Histology

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引用スタイル

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abstract = "Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.",

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