抄録
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.
本文言語 | 英語 |
---|---|
ページ(範囲) | 933-944 |
ページ数 | 12 |
ジャーナル | Histology and histopathology |
巻 | 25 |
号 | 7 |
出版ステータス | 出版済み - 7月 2010 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 病理学および法医学
- 組織学