Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

A. Tsubura, K. Yoshizawa, M. Kuwata, N. Uehara

研究成果: Contribution to journalReview article査読

66 被引用数 (Scopus)

抄録

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.

本文言語英語
ページ(範囲)933-944
ページ数12
ジャーナルHistology and histopathology
25
7
出版ステータス出版済み - 7 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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