Anterograde and retrograde signaling by an Aplysia neurotrophin forms a transsynaptic functional unit

Iksung Jin, Hiroshi Udo, Stefan Kassabov, Stylianos Kosmidis, Huixiang Zhu, Eric R. Kandel, Robert D. Hawkins

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Whereas short-term synaptic plasticity is often either pre- or postsynaptic, intermediate- and long-term plasticity generally require coordinated pre- and postsynaptic mechanisms. Thus, the transition from presynaptic short-term facilitation (STF) to intermediate-term facilitation (ITF) induced by 5HT at Aplysia sensory-to-motor neuron synapses requires the recruitment of postsynaptic mechanisms and activation of protein synthesis in both neurons. In the companion paper to this report, we found that presynaptic autocrine signaling by an Aplysia neurotrophin (ApNT) forms a positive feedback loop that drives the synapses from STF to ITF. Here we report that ApNT also acts through both anterograde and retrograde signaling to form a transsynaptic positive feedback loop that orchestrates cellular functions in both the presynaptic and postsynaptic neurons during the induction of ITF. These two feedback loops activate protein synthesis in each synaptic compartment, which in both cases depends on signaling from the other synaptic compartment. These results suggest that the pre- and postsynaptic compartments act as one functional unit during the consolidation of learning-related facilitation induced by 5HT.

元の言語英語
ページ(範囲)E10951-E10960
ジャーナルProceedings of the National Academy of Sciences of the United States of America
115
発行部数46
DOI
出版物ステータス出版済み - 11 13 2018

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Aplysia
Nerve Growth Factors
Synapses
Autocrine Communication
Neurons
Neuronal Plasticity
Motor Neurons
Proteins
Learning

All Science Journal Classification (ASJC) codes

  • General

これを引用

Anterograde and retrograde signaling by an Aplysia neurotrophin forms a transsynaptic functional unit. / Jin, Iksung; Udo, Hiroshi; Kassabov, Stefan; Kosmidis, Stylianos; Zhu, Huixiang; Kandel, Eric R.; Hawkins, Robert D.

:: Proceedings of the National Academy of Sciences of the United States of America, 巻 115, 番号 46, 13.11.2018, p. E10951-E10960.

研究成果: ジャーナルへの寄稿記事

Jin, Iksung ; Udo, Hiroshi ; Kassabov, Stefan ; Kosmidis, Stylianos ; Zhu, Huixiang ; Kandel, Eric R. ; Hawkins, Robert D. / Anterograde and retrograde signaling by an Aplysia neurotrophin forms a transsynaptic functional unit. :: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; 巻 115, 番号 46. pp. E10951-E10960.
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AU - Kosmidis, Stylianos

AU - Zhu, Huixiang

AU - Kandel, Eric R.

AU - Hawkins, Robert D.

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