Anti-allergic effect of strawberry extract

Akira Iwamoto, Aiko Inoue, Yuichi Inoue, Koji Yamada, Hirofumi Tachibana, Hiroharu Kawahara

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)


We examined the anti-allergic effect of strawberry extract on human peripheral blood mononuclear cells (PBMCs) and atopic dermatitis model mice NC/NgaTndCrlj. The addition of strawberry extract suppressed total IgE production in the cedar pollen antigen Cry j 1-stimulated PBMCs. Flow cytometric analysis showed that strawberry extract decreased the rate of CD3+CD4+ helper T cells by 17.3% and increased the rate of CD3+CD8+ cytotoxic T cells by 19.7% in PBMCs. Moreover, the extract inhibited the expression level of GATA3 that is the master regulator of type 2 helper T cells (Th2) in human primary pan T cells isolated from PBMCs. Oral administration of strawberry extract lowered dermatitis scores and serum IgE levels in mice. In addition, it also decreased the GATA3 expression level in mouse blood cells. These results revealed that strawberry extract suppressed the severity of atopic dermatitis through the down-regulation of serum IgE by inhibition of Th2 differentiation.

ジャーナルJournal of Functional Foods
出版ステータス出版済み - 10月 1 2013

!!!All Science Journal Classification (ASJC) codes

  • 食品科学
  • 医学(その他)
  • 栄養および糖尿病


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