Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu; Kuniyoshi Shimizu; Fumiko Konishi; Kiyoshi Noda; Shoichiro Kumamoto; Kenji Kurashiki; Ryuichiro Kondo

doi:10.1016/j.foodchem.2006.01.003

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Kenji Kurashiki, Ryuichiro Kondo

サスティナブル資源科学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

48 被引用数 (Scopus)

抄録

The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

本文言語	英語
ページ（範囲）	1691-1696
ページ数	6
ジャーナル	Food Chemistry
巻	100
号	4
DOI	https://doi.org/10.1016/j.foodchem.2006.01.003
出版ステータス	出版済み - 2007

!!!All Science Journal Classification (ASJC) codes

分析化学
食品科学

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10.1016/j.foodchem.2006.01.003

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title = "Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum",

abstract = "The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.",

author = "Jie Liu and Kuniyoshi Shimizu and Fumiko Konishi and Kiyoshi Noda and Shoichiro Kumamoto and Kenji Kurashiki and Ryuichiro Kondo",

year = "2007",

doi = "10.1016/j.foodchem.2006.01.003",

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T1 - Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

AU - Liu, Jie

AU - Shimizu, Kuniyoshi

AU - Konishi, Fumiko

AU - Noda, Kiyoshi

AU - Kumamoto, Shoichiro

AU - Kurashiki, Kenji

AU - Kondo, Ryuichiro

PY - 2007

Y1 - 2007

N2 - The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

AB - The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

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U2 - 10.1016/j.foodchem.2006.01.003

DO - 10.1016/j.foodchem.2006.01.003

M3 - Article

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SN - 0308-8146

VL - 100

SP - 1691

EP - 1696

JO - Food Chemistry

JF - Food Chemistry

IS - 4

ER -

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

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!!!All Science Journal Classification (ASJC) codes

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