Anti-CXCR3 staining is useful for detecting human cutaneous and mucosal mast cells

Noriko Fukiwake, Yoichi Moroi, Shinichi Imafuku, Teiichi Masuda, Hisashi Kokuba, Masutaka Furue, Kazunori Urabe

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抜粋

Human synovial mast cells (MC) can be immunolabelled with antihuman CXCR3 antibody (Ab) (clone 49801). We have investigated whether cutaneous and mucosal MC are stained with anti-CXCR3 Ab in paraffin-embedded sections. Immunohistochemical staining and immunofluorescence double staining assays were performed with anti-CXCR3, anti-tryptase, and anti-chymase Ab using normal skin, psoriatic skin lesions, and normal colon. When compared with tryptase and chymase staining, 100% of the cutaneous and 98% of the mucosal MC were positive for CXCR3. Anti-CXCR3 staining is a useful marker for human cutaneous and mucosal MC in paraffin-embedded sections.

元の言語英語
ページ(範囲)326-330
ページ数5
ジャーナルJournal of Dermatology
33
発行部数5
DOI
出版物ステータス出版済み - 5 1 2006

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All Science Journal Classification (ASJC) codes

  • Dermatology

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