Anti-ganglionic AChR antibodies in Japanese patients with motility disorders

Akihiro Mukaino, Hitomi Minami, Hajime Isomoto, Hitomi Hamamoto, Eikichi Ihara, Yasuhiro Maeda, Osamu Higuchi, Tohru Okanishi, Yohei Kokudo, Kazushi Deguchi, Fumisato Sasaki, Toshihito Ueki, Ken ya Murata, Takeshi Yoshida, Mistuyo Kinjo, Yoshihiro Ogawa, Akio Ido, Hidenori Matsuo, Kazuhiko Nakao, Shunya Nakane

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Background: The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO). Methods: First study: retrospective cohort study and laboratory investigation. Samples from 123 patients with seropositive AAG were obtained between 2012 and 2017. Second study: prospective study. Samples from 28 patients with achalasia and 14 patients with CIPO were obtained between 2014 and 2016, and 2013 and 2017, respectively. In the first study, we analyzed clinical profiles of seropositive AAG patients. In the second study, we compared clinical profiles, autonomic symptoms, and results of antibody screening between seropositive, seronegative achalasia, and CIPO groups. Results: In the first study, we identified 10 patients (8.1%) who presented with achalasia, or gastroparesis, or paralytic ileus. In the second study, we detected anti-gAChR Abs in 21.4% of the achalasia patients, and in 50.0% of the CIPO patients. Although patients with achalasia and CIPO demonstrated widespread autonomic dysfunction, bladder dysfunction was observed in the seropositive patients with CIPO as a prominent clinical characteristic of dysautonomia. Conclusions: These results demonstrate a significant prevalence of anti-gAChR antibodies in patients with achalasia and CIPO. Anti-gAChR Abs might mediate autonomic dysfunction, contributing to autoimmune mechanisms underlying these GI motility disorders.

元の言語英語
ページ(範囲)1227-1240
ページ数14
ジャーナルJournal of gastroenterology
53
発行部数12
DOI
出版物ステータス出版済み - 12 1 2018

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Intestinal Pseudo-Obstruction
Esophageal Achalasia
Antibodies
Cholinergic Receptors
Gastrointestinal Motility
Primary Dysautonomias
Gastroparesis
Autoantibodies
Urinary Bladder
Cohort Studies
Retrospective Studies
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Mukaino, A., Minami, H., Isomoto, H., Hamamoto, H., Ihara, E., Maeda, Y., ... Nakane, S. (2018). Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. Journal of gastroenterology, 53(12), 1227-1240. https://doi.org/10.1007/s00535-018-1477-8

Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. / Mukaino, Akihiro; Minami, Hitomi; Isomoto, Hajime; Hamamoto, Hitomi; Ihara, Eikichi; Maeda, Yasuhiro; Higuchi, Osamu; Okanishi, Tohru; Kokudo, Yohei; Deguchi, Kazushi; Sasaki, Fumisato; Ueki, Toshihito; Murata, Ken ya; Yoshida, Takeshi; Kinjo, Mistuyo; Ogawa, Yoshihiro; Ido, Akio; Matsuo, Hidenori; Nakao, Kazuhiko; Nakane, Shunya.

:: Journal of gastroenterology, 巻 53, 番号 12, 01.12.2018, p. 1227-1240.

研究成果: ジャーナルへの寄稿記事

Mukaino, A, Minami, H, Isomoto, H, Hamamoto, H, Ihara, E, Maeda, Y, Higuchi, O, Okanishi, T, Kokudo, Y, Deguchi, K, Sasaki, F, Ueki, T, Murata, KY, Yoshida, T, Kinjo, M, Ogawa, Y, Ido, A, Matsuo, H, Nakao, K & Nakane, S 2018, 'Anti-ganglionic AChR antibodies in Japanese patients with motility disorders', Journal of gastroenterology, 巻. 53, 番号 12, pp. 1227-1240. https://doi.org/10.1007/s00535-018-1477-8
Mukaino, Akihiro ; Minami, Hitomi ; Isomoto, Hajime ; Hamamoto, Hitomi ; Ihara, Eikichi ; Maeda, Yasuhiro ; Higuchi, Osamu ; Okanishi, Tohru ; Kokudo, Yohei ; Deguchi, Kazushi ; Sasaki, Fumisato ; Ueki, Toshihito ; Murata, Ken ya ; Yoshida, Takeshi ; Kinjo, Mistuyo ; Ogawa, Yoshihiro ; Ido, Akio ; Matsuo, Hidenori ; Nakao, Kazuhiko ; Nakane, Shunya. / Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. :: Journal of gastroenterology. 2018 ; 巻 53, 番号 12. pp. 1227-1240.
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abstract = "Background: The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO). Methods: First study: retrospective cohort study and laboratory investigation. Samples from 123 patients with seropositive AAG were obtained between 2012 and 2017. Second study: prospective study. Samples from 28 patients with achalasia and 14 patients with CIPO were obtained between 2014 and 2016, and 2013 and 2017, respectively. In the first study, we analyzed clinical profiles of seropositive AAG patients. In the second study, we compared clinical profiles, autonomic symptoms, and results of antibody screening between seropositive, seronegative achalasia, and CIPO groups. Results: In the first study, we identified 10 patients (8.1{\%}) who presented with achalasia, or gastroparesis, or paralytic ileus. In the second study, we detected anti-gAChR Abs in 21.4{\%} of the achalasia patients, and in 50.0{\%} of the CIPO patients. Although patients with achalasia and CIPO demonstrated widespread autonomic dysfunction, bladder dysfunction was observed in the seropositive patients with CIPO as a prominent clinical characteristic of dysautonomia. Conclusions: These results demonstrate a significant prevalence of anti-gAChR antibodies in patients with achalasia and CIPO. Anti-gAChR Abs might mediate autonomic dysfunction, contributing to autoimmune mechanisms underlying these GI motility disorders.",
author = "Akihiro Mukaino and Hitomi Minami and Hajime Isomoto and Hitomi Hamamoto and Eikichi Ihara and Yasuhiro Maeda and Osamu Higuchi and Tohru Okanishi and Yohei Kokudo and Kazushi Deguchi and Fumisato Sasaki and Toshihito Ueki and Murata, {Ken ya} and Takeshi Yoshida and Mistuyo Kinjo and Yoshihiro Ogawa and Akio Ido and Hidenori Matsuo and Kazuhiko Nakao and Shunya Nakane",
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T1 - Anti-ganglionic AChR antibodies in Japanese patients with motility disorders

AU - Mukaino, Akihiro

AU - Minami, Hitomi

AU - Isomoto, Hajime

AU - Hamamoto, Hitomi

AU - Ihara, Eikichi

AU - Maeda, Yasuhiro

AU - Higuchi, Osamu

AU - Okanishi, Tohru

AU - Kokudo, Yohei

AU - Deguchi, Kazushi

AU - Sasaki, Fumisato

AU - Ueki, Toshihito

AU - Murata, Ken ya

AU - Yoshida, Takeshi

AU - Kinjo, Mistuyo

AU - Ogawa, Yoshihiro

AU - Ido, Akio

AU - Matsuo, Hidenori

AU - Nakao, Kazuhiko

AU - Nakane, Shunya

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO). Methods: First study: retrospective cohort study and laboratory investigation. Samples from 123 patients with seropositive AAG were obtained between 2012 and 2017. Second study: prospective study. Samples from 28 patients with achalasia and 14 patients with CIPO were obtained between 2014 and 2016, and 2013 and 2017, respectively. In the first study, we analyzed clinical profiles of seropositive AAG patients. In the second study, we compared clinical profiles, autonomic symptoms, and results of antibody screening between seropositive, seronegative achalasia, and CIPO groups. Results: In the first study, we identified 10 patients (8.1%) who presented with achalasia, or gastroparesis, or paralytic ileus. In the second study, we detected anti-gAChR Abs in 21.4% of the achalasia patients, and in 50.0% of the CIPO patients. Although patients with achalasia and CIPO demonstrated widespread autonomic dysfunction, bladder dysfunction was observed in the seropositive patients with CIPO as a prominent clinical characteristic of dysautonomia. Conclusions: These results demonstrate a significant prevalence of anti-gAChR antibodies in patients with achalasia and CIPO. Anti-gAChR Abs might mediate autonomic dysfunction, contributing to autoimmune mechanisms underlying these GI motility disorders.

AB - Background: The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO). Methods: First study: retrospective cohort study and laboratory investigation. Samples from 123 patients with seropositive AAG were obtained between 2012 and 2017. Second study: prospective study. Samples from 28 patients with achalasia and 14 patients with CIPO were obtained between 2014 and 2016, and 2013 and 2017, respectively. In the first study, we analyzed clinical profiles of seropositive AAG patients. In the second study, we compared clinical profiles, autonomic symptoms, and results of antibody screening between seropositive, seronegative achalasia, and CIPO groups. Results: In the first study, we identified 10 patients (8.1%) who presented with achalasia, or gastroparesis, or paralytic ileus. In the second study, we detected anti-gAChR Abs in 21.4% of the achalasia patients, and in 50.0% of the CIPO patients. Although patients with achalasia and CIPO demonstrated widespread autonomic dysfunction, bladder dysfunction was observed in the seropositive patients with CIPO as a prominent clinical characteristic of dysautonomia. Conclusions: These results demonstrate a significant prevalence of anti-gAChR antibodies in patients with achalasia and CIPO. Anti-gAChR Abs might mediate autonomic dysfunction, contributing to autoimmune mechanisms underlying these GI motility disorders.

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