Anti-inflammatory effects of kinins via microglia in the central nervous system

Mami Noda, Helmut Kettenmann, Keiji Wada

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca2+, microglial migration, and increases the release of nitric oxide and prostaglandin E2. On the other hand, BK attenuates lipopolysaccharide-activated TNF-α and IL-1β release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.

本文言語英語
ページ(範囲)167-171
ページ数5
ジャーナルBiological chemistry
387
2
DOI
出版ステータス出版済み - 2 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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