Anti-monocyte chemoattractant protein-1 gene therapy for cardiovascular diseases.

Shiro Kitamoto, Kensuke Egashira

    研究成果: Contribution to journalReview article査読

    29 被引用数 (Scopus)

    抄録

    Recent studies have revealed that increased expression of monocyte chemoattractant protein (MCP)-1 plays a central role in the pathogenesis of cardiovascular diseases. 7ND is the amino-terminal deletion mutant of human MCP-1 and works as a dominant negative inhibitor of MCP-1. We devised a new strategy of anti-MCP-1 gene therapy by transfecting the 7ND gene into skeletal muscles. 7ND gene transfection suppressed arteriosclerotic changes induced by chronic inhibition of nitric oxide synthesis in rats and inhibited the development, progression and destabilization of atherosclerosis in apolipoprotein E knockout mice. This strategy also reduced restenosis after balloon injury in rats, rabbits and monkeys, and reduced neointimal formation after stent implantation in rabbits and monkeys. This new strategy can be a useful and feasible gene therapy against MCP-1 related cardiovascular diseases.

    本文言語英語
    ページ(範囲)393-400
    ページ数8
    ジャーナルExpert review of cardiovascular therapy
    1
    3
    DOI
    出版ステータス出版済み - 9 2003

    All Science Journal Classification (ASJC) codes

    • 内科学
    • 循環器および心血管医学

    フィンガープリント

    「Anti-monocyte chemoattractant protein-1 gene therapy for cardiovascular diseases.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル