Anti-oxidant and aldose reductase inhibitory activity of Piper betle extracts

Sri Fatmawati, Kuniyoshi Shimizu

研究成果: 著書/レポートタイプへの貢献

抜粋

Piper betle, known as daun sirih, is one of popular jamu ingredients which could be consumed freshly from the natural product resources by Indonesian people as traditional medicine. The present study is the primary article on human aldose reductase inhibition and also antioxidant activity of P. betle leaves extracts. The ethanol extract of P. betle exhibited the most inhibitory activity of the aldose reductase enzyme among extracts. It was discovered to present an IC50 value of 18.8 μg/mL for in vitro human aldose reductase and showed antioxidant activity by ORAC assay with value of 3861.2 ± 451.0 μmol Trolox Equivalent/g extract. Further investigation on the chemical components of the ethanol extract showed a total of 14 compounds by GC-MS analysis. The major compounds were bisphenol A (13) (34.4%) isoxylic acid (3) (13.8%), trans-phytol (11) (6.6%) and octadecyl aldehyde (14) (6.4%). These results implied that P. betle leaves should be prospective as an aldose reductase inhibitor.

元の言語英語
ホスト出版物のタイトルProceedings of the Pakistan Academy of Sciences
ホスト出版物のサブタイトルPart B
出版者Giunti
ページ75-82
ページ数8
エディション3BSpecial Issue
出版物ステータス出版済み - 9 2019

出版物シリーズ

名前Proceedings of the Pakistan Academy of Sciences: Part B
番号3BSpecial Issue
56
ISSN(印刷物)2518-4261
ISSN(電子版)2518-427X

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

これを引用

Fatmawati, S., & Shimizu, K. (2019). Anti-oxidant and aldose reductase inhibitory activity of Piper betle extracts. : Proceedings of the Pakistan Academy of Sciences: Part B (3BSpecial Issue 版, pp. 75-82). (Proceedings of the Pakistan Academy of Sciences: Part B; 巻数 56, 番号 3BSpecial Issue). Giunti.