Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue

Shigenobu Kanba, Elliott Richelson

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

Guinea pig hippocampus dissociated by mechanical means into uniform clumps of cells (∼ 100 μm in diameter) contains histamine receptors (H1 and H2) which mediate the formation of cyclic AMP. In this preparation, antidepressants are very potent antagonists of histamine H1 receptors but are weak antagonists of histamine H2 receptors. The latter result is contrary to data derived by others using homogenates of the guinea pig hippocampus and seems to dispel the idea that antidepressants derive their efficacy by blocking histamine H2 receptors in brain.

本文言語英語
ページ(範囲)313-318
ページ数6
ジャーナルEuropean Journal of Pharmacology
94
3-4
DOI
出版ステータス出版済み - 10 28 1983

All Science Journal Classification (ASJC) codes

  • 薬理学

フィンガープリント

「Antidepressants are weak competitive antagonists of histamine H<sub>2</sub> receptors in dissociated brain tissue」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル