Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia

Irawan Wijaya Kusuma, Enos Tangke Arung, Enih Rosamah, Sri Purwatiningsih, Harlinda Kuspradini, Syafrizal, Juli Astuti, Yong Ung Kim, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

33 被引用数 (Scopus)

抄録

An active compound from the bulb of Eleutherine americana L. Merr. (Iridaceae) collected from East Kalimantan, Indonesia, was tested for its antidermatophyte and antimelanogenesis activity. Antifungal assay-directed fractionation of the n-hexane-soluble fraction of the methanolic extract of the bulb of E. americana led to the isolation of 1 as an active compound. The compound was identified as the naphthoquinone eleutherin by EI-MS and 1H-, 13C-, and two-dimensional NMR analyses. Antidermatophyte assay of 1 at concentrations of 10, 20, 40, 60, and 80 μg/disk and myconazole, a commercial antidermatophyte, at 10 μg/disk displayed 7, 8, 13, 16, 17, and 14 mm of inhibition zone against Trichophyton mentagrophytes, respectively. In a melanin formation inhibition assay, compound 1 displayed potent antimelanogenesis activity at 5 ppm with low toxicity compared with arbutin, a commercial skin-whitening agent. The results showed the high potential of 1, an active compound from E. americana, to be applied as an antidermatophyte and antimelanogenesis agent.

本文言語英語
ページ(範囲)223-226
ページ数4
ジャーナルJournal of Natural Medicines
64
2
DOI
出版ステータス出版済み - 4 2010

All Science Journal Classification (ASJC) codes

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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