抄録
We found an antigen-specific factor capable of augmenting delayed-type hypersensitivity (DTH) in the culture supernatant of the mixture of immune T cells and specific antigen, or in the serum of mice immunized with xenogeneic erythrocytes and elicited for DTH footpad reaction.Previous experiments on the genetic restriction of this factor (DTH-augmentation factor; DAF) indicated that DAF activity was effective across the MHC-barrier in OH/He (H-2k) - BALB/c (H-2d) system.The genetic restriction between DAF and its acceptor cells was then investigated precisely using Igh (immunoglobulin heavy chain locus)-congeneic mice: 1) Expression of DAF activity was MHC-nonrestricted, 2) but was restricted by the Ighlinked gene on the 12th chromosome, 3) such Igh-linked gene restriction was also demonstrated by an absorption test with normal spleen cells.The acceptor cells for DAF were Thy-1+, L3T4+, Lyt-2− T cells.
本文言語 | 英語 |
---|---|
ページ(範囲) | 24-34 |
ページ数 | 11 |
ジャーナル | Immunobiology |
巻 | 176 |
号 | 1-2 |
DOI | |
出版ステータス | 出版済み - 1987 |
!!!All Science Journal Classification (ASJC) codes
- 免疫アレルギー学
- 免疫学
- 血液学